It’s in your DNA - your body’s experiences become imprinted as methylation signatures!

David Einar

The aim of our research is to understand how infections like COVID-19 and tuberculosis can induce epigenetic changes to our DNA.

In our studies, we have observed that people who are exposed to tuberculosis carry epigenetic marks in the DNA of immune cells and other cells. More specifically, we study DNA methylation signatures and we are currently investigating whether we can use this technology for diagnosis, treatment monitoring and contact tracing in the management of tuberculosis. We have also observed that COVID-19 infection rewires the DNA of our immune cells and that people suffering from post covid have unique marks in their DNA that could both explain why they are not feeling well and be used to develop new diagnostic tools.

Through a generous grant from the Swedish Heart Lung Foundation we are now able to investigate how epigenetic signatures evolve over time during infection and search for explanations to why some people are more susceptible than other to infectious disease or develop long-term sequelae. We also study the epigenetic program of immune cells of babies to mothers with tuberculosis and COVID-19, in order to understand how epigenetic signals are transmitted to the next generation. 


News from LiU

Kvinna på tågstation i Europa.

Take the train to the conference

Is it possible to pursue an academic career while cutting down on air travel? Karolina Kristenson and Kristofer Hedman don’t see any problem with that. They took the train to Milan and had time for both work and socialising along the way.

Man on bicycle being supervised by male physician.

“We’re beginning to understand post-COVID better now”

The understanding of why some people experience lingering symptoms following COVID-19 has increased rapidly. Swedish researchers have now published an overview of research findings on breathing and heart function problems in post-COVID condition.

Researchers in laboratory.

Post-COVID syndrome visible in DNA

A reprogramming of which genes are active, and which are not, is visible in post-COVID sufferers. In a study on a small group of individuals, genes associated with taste and smell, as well as cell metabolism, were affected.


Group members