Presentation

Psoriasis is a common skin disease affecting about 3% of the population. It is an immunologically mediated, autoimmune disorder occurring in genetically predisposed individuals. The psoriatic skin lesion shows an excessive proliferation and disturbed differentiation of epidermal cells and new vessel formation in the underlying dermis, a combination of changes reminiscent of those seen in cancer. Importantly however, the epithelial proliferation in psoriasis remains under strict control while the hallmark of cancer is its lack of epithelial growth control.

Our research program has been made possible by a generous donation from the Ingrid Asp Foundation. Our ultimate goal is to obtain an improved understanding of the pathogenesis of psoriasis and to find new modalities for its therapy.

Key Research

The research of the group is focused on investigating the disease and includes studies of local and systemic immunological mechanisms, mechanisms behind blood vessel formation, cell differentiation and apoptosis, underlying genetic components and co-morbidities in psoriasis. For this purpose, a large and well-characterized patient material has been collected consisting of plasma and serum, isolated leukocytes, skin biopsies, isolated keratinocytes and DNA. In addition, several human cell lines and isolated primary cells are used.

Publications
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2019

Psoriasis research at LiU
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