Photo of Charlotta Enerbäck

Charlotta Enerbäck



Psoriasis is a common skin disease affecting about 3% of the population. It is an immunologically mediated, autoimmune disorder occurring in genetically predisposed individuals. The psoriatic skin lesion shows an excessive proliferation and disturbed differentiation of epidermal cells and new vessel formation in the underlying dermis, a combination of changes reminiscent of those seen in cancer. Importantly however, the epithelial proliferation in psoriasis remains under strict control while the hallmark of cancer is its lack of epithelial growth control.

Our research program has been made possible by a generous donation from the Ingrid Asp Foundation. Our ultimate goal is to obtain an improved understanding of the pathogenesis of psoriasis and to find new modalities for its therapy.

Key Research

The research of the group is focused on investigating the disease and includes studies of local and systemic immunological mechanisms, mechanisms behind blood vessel formation, cell differentiation and apoptosis, underlying genetic components and co-morbidities in psoriasis. For this purpose, a large and well-characterized patient material has been collected consisting of plasma and serum, isolated leukocytes, skin biopsies, isolated keratinocytes and DNA. In addition, several human cell lines and isolated primary cells are used.



Debojyoti Das, Joana Thimjo, Andrea Lebena, Annie Guo, Charlotta Enerbäck, Johnny Ludvigsson (2024) Breastfeeding decreases the risk of developing psoriasis through to early adulthood British Journal of Dermatology Continue to DOI


Deepti Verma, Nada-Katarina Kasic, Freja Jeppsson, Cecilia Bivik Eding, Malgorzata Lysiak, Shora Zamani Fekri, Jyotirmoy Das, Charlotta Enerbäck (2023) Differential DNA Methylation of MicroRNA- Encoding Genes in Psoriatic Epidermis Highlights the Wnt Pathway Journal of Investigative Dermatology, Vol. 143, p. 1594-1597 Continue to DOI


Cecilia Bivik Eding, Ines Köhler, Deepti Verma, Florence Sjögren, Claudia Bamberg, Stella Karsten, Therese Pham, Martin Scobie, Thomas Helleday, Ulrika Warpman Berglund, Charlotta Enerbäck (2021) MTH1 Inhibitors for the Treatment of Psoriasis Journal of Investigative Dermatology, Vol. 141, p. 2037-2048 Continue to DOI
Deepti Verma, Shora Zamani Fekri, Gunnthorunn Sigurdardottir, Cecilia Bivik, Charlotta Sandin, Charlotta Enerbäck (2021) Enhanced Inflammasome Activity in Patients with Psoriasis Promotes Systemic Inflammation Journal of Investigative Dermatology, Vol. 141, p. 586-595.e5 Continue to DOI
Kamran Ghoreschi, Anna Balato, Charlotta Enerbäck, Robert Sabat (2021) Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis The Lancet, Vol. 397, p. 754-766 Continue to DOI

Psoriasis research at LiU