Photo of Eleonore von Castelmur

Eleonore von Castelmur

Associate Professor, Docent

I use integrated structural biology techniques to gain a better understanding of the molecular mechanisms underlying protein function in health and disease




Afshan Begum, Jun Zhang, Dean Derbyshire, Xiongyu Wu, Peter Konradsson, Per Hammarström, Eleonore von Castelmur (2023) Transthyretin Binding Mode Dichotomy of Fluorescent trans-Stilbene Ligands ACS Chemical Neuroscience, Vol. 14, p. 820-828 Continue to DOI
Nghia Nguyen Thi Minh, Afshan Begum, Jun Zhang, Petter Leira, Yogesh Todarwal, Mathieu Linares, Patrick Norman, Dean Derbyshire, Eleonore von Castelmur, Mikael Lindgren, Per Hammarström, Carolin Koenig (2023) Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study Journal of Physical Chemistry B, Vol. 127, p. 6628-6635 Continue to DOI
Bartosz Malinski, Jacopo Vertemara, Elena Faustini, Claes Ladenvall, Anna Norberg, Yuming Zhang, Eleonore von Castelmur, Panagiotis Baliakas, Renata Tisi, Jörg Cammenga, Francisca Lottersberger (2023) Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity Human Molecular Genetics, Vol. 32, p. 2901-2912 Continue to DOI


Anna Wehlin, Irina Cornaciu, Jose Antonio Marquez, Anastassis Perrakis, Eleonore von Castelmur (2022) Crystal structure of the phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain Journal of Structural Biology, Vol. 214, Article 107903 Continue to DOI
Anirban Sengupta, Mohammad Azharuddin, Maria Eugenia Cardona Gomez, Claudia Devito, Eleonore von Castelmur, Anna Wehlin, Zuzanna Pietras, Maria Sunnerhagen, Robert Selegård, Daniel Aili, Ali Alamer, Jorma Hinkula, Noha Al-Otaibi (2022) Intranasal Coronavirus SARS-CoV-2 Immunization with Lipid Adjuvants Provides Systemic and Mucosal Immune Response against SARS-CoV-2 S1 Spike and Nucleocapsid Protein Vaccines, Vol. 10, Article 504 Continue to DOI


Jacqueline Staring, Eleonore von Castelmur, Vincent A Blomen, Lisa G van den Hengel, Markus Brockmann, Jim Baggen, Hendrik Jan Thibaut, Joppe Nieuwenhuis, Hans Janssen, Frank J M van Kuppeveld, Anastassis Perrakis, Jan E Carette, Thijn R Brummelkamp (2017) PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature, Vol. 541, p. 412-416 Continue to DOI


Thomas Zacharchenko, Eleonore von Castelmur, Daniel J Rigden, Olga Mayans (2015) Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding. Biochemical Society Transactions, Vol. 43, p. 850-5 Continue to DOI
Yoshitaka Hiruma, Carlos Sacristan, Spyridon T Pachis, Athanassios Adamopoulos, Timo Kuijt, Marcellus Ubbink, Eleonore von Castelmur, Anastassis Perrakis, Geert J P L Kops (2015) Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling Science, Vol. 348, p. 1264-1267 Continue to DOI


Barbara Franke, Alexander Gasch, Dayté Rodriguez, Mohamed Chami, Muzamil M Khan, Rüdiger Rudolf, Jaclyn Bibby, Akira Hanashima, Julijus Bogomolovas, Eleonore von Castelmur, Daniel J Rigden, Isabel Uson, Siegfried Labeit, Olga Mayans (2014) Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1 Open Biology, Vol. 4, Article 130172 Continue to DOI


Wilco Nijenhuis, Eleonore von Castelmur, Dene Littler, Valeria De Marco, Eelco Tromer, Mathijs Vleugel, Maria H J van Osch, Berend Snel, Anastassis Perrakis, Geert J P L Kops (2013) A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B Journal of Cell Biology, Vol. 201, p. 217-231 Continue to DOI


Saskia J E Suijkerbuijk, Teunis J P van Dam, G Elif Karagöz, Eleonore von Castelmur, Nina C Hubner, Afonso M S Duarte, Mathijs Vleugel, Anastassis Perrakis, Stefan G D Rüdiger, Berend Snel, Geert J P L Kops (2012) The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase Developmental Cell, Vol. 22, p. 1321-1329 Continue to DOI
Johan A. Strumpfer, Eleonore von Castelmur, Barbara Franke, Sonia Barbieri, Julijus Bogomolovas, Hiroshi Qadota, Petr Konarv, Dmitri Svergun, Siegfried Labeit, Klaus Schulten, Guy Benian, Olga Mayans (2012) Stretching of Twitchin Kinase Biophysical Journal, Vol. 102, p. 361a-362a Continue to DOI
Eleonore von Castelmur, Johan Strümpfer, Barbara Franke, Julijus Bogomolovas, Sonia Barbieri, Hiroshi Qadota, Petr V Konarev, Dmitri I Svergun, Siegfried Labeit, Guy M Benian, Klaus Schulten, Olga Mayans (2012) Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, p. 13608-13613 Continue to DOI
Tatjana Heidebrecht, Alexander Fish, Eleonore von Castelmur, Kenneth A Johnson, Giuseppe Zaccai, Piet Borst, Anastassis Perrakis (2012) Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding Journal of the American Chemical Society, Vol. 134, p. 13357-13365 Continue to DOI


Eric H Lee, Jen Hsin, Eleonore von Castelmur, Olga Mayans, Klaus Schulten (2010) Tertiary and Secondary Structure Elasticity of a Six-Ig Titin Chain Biophysical Journal, Vol. 98, p. 1085-1095 Continue to DOI


Alexandre Urzhumtsev, Eleonore von Castelmur, Olga Mayans (2008) Ultralow-resolution ab initio phasing of filamentous proteins: crystals from a six-Ig fragment of titin as a case study. Acta Crystallographica Section D: Biological Crystallography, Vol. 64, p. 478-486 Continue to DOI
Michael Mrosek, Sebastian Meier, Zöhre Ucurum-Fotiadis, Eleonore von Castelmur, Erik Hedbom, Ariel Lustig, Stephan Grzesiek, Dietmar Labeit, Siegfried Labeit, Olga Mayans (2008) Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold. Biochemistry, Vol. 47, p. 10722-10730 Continue to DOI
Eleonore von Castelmur, Marco Marino, Dmitri I Svergun, Laurent Kreplak, Zöhre Ucurum-Fotiadis, Petr V Konarev, Alexandre Urzhumtsev, Dietmar Labeit, Siegfried Labeit, Olga Mayans (2008) A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, p. 1186-1191 Continue to DOI


Michael Mrosek, Dietmar Labeit, Stephanie Witt, Heiko Heerklotz, Eleonore von Castelmur, Siegfried Labeit, Olga Mayans (2007) Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin. The FASEB Journal, Vol. 21, p. 1383-1392 Continue to DOI

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