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Helena Enocsson

Docent, PhD, Researcher in rheumatology with focus on systemic lupus erythematosus (SLE)

Biomarkers of inflammation and organ damage in systemic lupus erythematosus (SLE)

SLE is an autoimmune disease which may affect multiple organ systems. It's heterogeneity implies clinical challenges regarding diagnostics, follow-up and treatment. About 90% of the patients are women.

The disease course in SLE is characterized by flares and remissions. Treatment as well as disease activity may cause permanent organ damage which has an impact on the quality of life, morbidity and mortality.

Our research group study rheumatic diseases from a clinical- as well as experimental perspective. The focus of my research is biomarkers of inflammation and organ damage in SLE and other inflammatory diseases, with a special interest in acute phase proteins, autoantibodies and interferon alpha.

The overall aim is to find biomarkers for improved diagnostics, follow-up and targeted therapy in SLE.

About me

Education

  • Medical Doctor, 2024

  • PhD, 2014

  • Master of Medical Science in Medical Biology, 2008

Teaching

  • Supervisor of degree projects
  • Supervisor of tutorial groups (the Medical program, Medical Biology, etc.)
  • Laboratory teaching

Membership and networks

  • The Swedish Society for Rheumatology (SRF)
  • The Swedish SLE network
  • DISSECT consortium (Dissecting disease mechanisms in three systemic inflammatory autoimmune diseases with an interferon signature)
  • Mucosa Infection and Inflammation Center (MIIC)
  • Ingrid Asp Kidney Research Center

Publications

2025

Jesper Karlsson, Lina Wirestam, Hanna Duan, Suhana Ahmad, Daniel Appelgren, Helena Enocsson, Jonas Wetterö, Christopher Sjöwall (2025) Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation Frontiers in Immunology, Vol. 16, Article 1578372 (Article in journal) Continue to DOI
Matteo Bianchi, Sergey V. Kozyrev, Antonella Notarnicola, Johanna K. Sandling, Mats Pettersson, Dag Leonard, Christopher Sjöwall, Iva Gunnarsson, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Andreas Jonsen, Elisabet Svenungsson, Helena Enocsson, Marika Kvarnstrom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B. Norheim, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Per Eriksson, Thomas Mandl, Roald Omdal, Leonid Padyukov, Helena Andersson, Oyvind Molberg, Louise Pyndt Diederichsen, Ann-Christine Syvanen, Marie Wahren-Herlenius, Gunnel Nordmark, Ingrid E. Lundberg, Lars Ronnblom, Kerstin Lindblad-Toh (2025) Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases Arthritis & Rheumatology, Vol. 77, p. 212-225 (Article in journal) Continue to DOI

2024

Helena Enocsson, Ingrid E. Lundberg, Martin Herrmann, Ioannis Parodis, Christopher Sjöwall (2024) Editorial: Autoantibodies for diagnostics, prognostics, and surveillance in autoimmune disease Frontiers in Medicine, Vol. 11, Article 1491035 (Article in journal) Continue to DOI
Linnea Lindelof, Solbritt Rantapaa-Dahlqvist, Christian Lundtoft, Johanna K. Sandling, Dag Leonard, Ahmed Sayadi, Lars Ronnblom, Helena Enocsson, Christopher Sjöwall, Andreas Jonsen, Anders A. Bengtsson, Mun-Gwan Hong, Lina-Marcela Diaz-Gallo, Matteo Bianchi, Sergey V Kozyrev, Kerstin Lindblad-Toh, Kristina Nilsson Ekdahl, Bo Nilsson, Iva Gunnarsson, Elisabet Svenungsson, Oskar Eriksson (2024) A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile Journal of Autoimmunity, Vol. 143, Article 103166 (Article in journal) Continue to DOI

2023

Lina Wirestam, Frida Jönsson, Helena Enocsson, Christina Svensson, Maria Weiner, Jonas Wetterö, Helene Zachrisson, Per Eriksson, Christopher Sjöwall (2023) Limited Association between Antibodies to Oxidized Low-Density Lipoprotein and Vascular Affection in Patients with Established Systemic Lupus Erythematosus International Journal of Molecular Sciences, Vol. 24, Article 8987 (Article in journal) Continue to DOI

News

Blood sampling in clinical setting from finger.

C-reactive protein reduces immune response in inflammatory disease

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers now show that this protein has a beneficial function in SLE, an inflammatory disease. But this is true only for one of CRP’s two forms, according to the study.

Organisation

Teaser image for the division II at BKV.

Division of Inflammation and Infection (II)

The Division of Inflammation and Infection (II) includes clinical subject areas such as Immunology, Rheumatology, Pathology and Microbiology.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.
Five people in a laboratory.

Faculty of Medicine and Health Sciences (MEDFAK)

The Faculty of Medicine and Health Sciences conducts research and education within medicine, healthcare and public health.

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