Photo of Mehrdad Rafat

Mehrdad Rafat

Adjunct Associate Professor

Presentation

Dr. Rafat received his Masters and Ph.D. degrees in Chemical and Biological Engineering from the University of Ottawa (Canada) with specialization in Biomaterials and Tissue Engineering. He is the senior author of more than 50 refereed publications and the inventor of five patents. Dr. Rafat co-developed the first clinically-tested bioengineered cornea at the University of Ottawa and Linköping University. Dr. Rafat’s achievement earned him the Government of Canada’s NSERC Innovation Challenge Award in 2008 and the Ontario Centers of Excellence Industrial Fellowship Award in 2006 (both awards honor Canada’s brightest minds, who have demonstrated an entrepreneurial spirit by identifying ways in which their research results can be developed into products and processes to benefit all). He has further developed the bioengineered cornea technology in his group at Linköping University and taken it to the next level toward commercialization. His career spans a broad range of professional experiences–from working as a researcher and lecturer in academia, a medical devices regulator at the Canadian Government (Health Canada), and a consultant to biotech industries. Dr. Rafat received two prestigious awards/grants from the European Research Agency including FP7 Marie Curie Incoming Fellowship Award (IIF) and FP7 Career Integration Grant. He is also a co-recipient (co-applicant) of the EU Arrest Blindness project and plays a key role in the success of that project. He is also one of the founders of LinkoCARE Life Sciences AB, a start-up/spinoff of Linköping University focused on GMP production and commercialization of bioengineered corneas.  Through his career, Dr. Rafat has been closely working and collaborating with many excellent clinicians around the world on transplantation of bioengineered corneas in patients helping them gain their vision back.

Publications

2023

Maria Xeroudaki, Mehrdad Rafat, Petros Moustardas, Anthonny Mukwaya, Shideh Tabe, Marco Bellisario, Beatrice Peebo, Neil Lagali (2023) A double-crosslinked nanocellulose-reinforced dexamethasone-loaded collagen hydrogel for corneal application and sustained anti-inflammatory activity Acta Biomaterialia, Vol. 172, p. 234-248 (Article in journal) Continue to DOI
Mehrdad Rafat, Mahmoud Jabbarvand, Namrata Sharma, Maria Xeroudaki, Shideh Tabe, Raha Omrani, Muthukumar Thangavelu, Anthonny Mukwaya, Per Fagerholm, Anton Lennikov, Farshad Askarizadeh, Neil Lagali (2023) Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts Nature Biotechnology, Vol. 41, p. 70-81 (Article in journal) Continue to DOI

2020

Neil S Lagali, Mehrdad Rafat (2020) Femtosecond Laser-Assisted Surgery for Implantation of Bioengineered Corneal Stroma to Promote Corneal Regeneration. Corneal Regeneration: Methods and Protocols, p. 197-214 (Chapter in book) Continue to DOI
Maria Xeroudaki, Muthukumar Thangavelu, Anton Lennikov, Anjula Ratnayake, Jovana Bisevac, Goran Petrovski, Per Fagerholm, Mehrdad Rafat, Neil Lagali (2020) A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery Scientific Reports, Vol. 10, Article 16936 (Article in journal) Continue to DOI
Daniele Spinozzi, Alina Miron, Jessica T. Lie, Mehrdad Rafat, Neil Lagali, Gerrit R. J. Melles, Sorcha Ni Dhubhghaill, Isabel Dapena, Silke Oellerich (2020) In Vitro Evaluation and Transplantation of Human Corneal Endothelial Cells Cultured on Biocompatible Carriers Cell Transplantation, Vol. 29, Article 0963689720923577 (Article in journal) Continue to DOI

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