Photo of Walker Jackson

Walker Jackson

Associate Professor

I study how specific brain regions are targeted in various neurodegenerative diseases.

Selective Vulnerability to Neurodegenerative Diseases

We use mouse genetic tools to understand how specific brain regions are affected by neurodegenerative processes.

We also are interested in understanding how poor sleep affects the onset and progression of neurodegenerative disease. We address these problems by developing models of diseases and tools to study them. One of our main technical focuses in recent years is to study how gene regulation in specific cell types is affected by neurodegenerative disease and sleep loss, using genetically encoded tools and next generation sequencing techniques. Manipulation of gene sequence and activity with CRISPR/Cas based methods is also a strength of the lab.

 

News

Research

Publications

Publications in DiVA

2023

Sonia M. Vallabh, Dan Zou, Rose Pitstick, Jill OMoore, Janet Peters, Derek Silvius, Jasna Kriz, Walker Jackson, George A. Carlson, Eric Vallabh Minikel, Deborah E. Cabin (2023) Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease Journal of Virology, Vol. 97 Continue to DOI
Maria I. Arifin, Lech Kaczmarczyk, Doris Zeng, Samia Hannaoui, Chi Lee, Sheng Chun Chang, Gordon Mitchell, Debbie McKenzie, Michael Beekes, Walker Jackson, Sabine Gilch (2023) Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Article e2221060120 Continue to DOI
Hedayat Rahin, Walker Jackson, Magnus Thordstein (2023) Effect of Transcutaneous Spinal Direct Current Stimulation in Patients with Painful Polyneuropathy and Influence of Possible Predictors of Efficacy including BDNF Polymorphism: A Randomized, Sham-Controlled Crossover Study Brain Sciences, Vol. 13, Article 229 Continue to DOI
Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Magadi, Walker Jackson (2023) Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntingtons disease mice Acta neuropathologica communications, Vol. 11, Article 17 Continue to DOI
Walker Jackson (2023) Etiology matters: genetic and acquired prion diseases engage different mechanisms at a presymptomatic stage Neural Regeneration Research, Vol. 18, p. 2707-2708 Continue to DOI

2022

Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhiannan H. Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J. Testaquadra, Stefan Bonn, Walker S. Jackson (2022) Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice PLoS Pathogens, Vol. 18, Article e1010747 Continue to DOI
Susanne Bauer, Lars Dittrich, Lech Kaczmarczyk, Melvin Schleif, Rui Benfeitas, Walker Jackson (2022) Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons Life Science Alliance, Vol. 5, Article e202201530 Continue to DOI
Alana M. Thackray, Brian Lam, Erin E. McNulty, Amy V Nalls, Candace K. Mathiason, Srivathsa Magadi, Walker Jackson, Olivier Andreoletti, Cristobal Marrero-Winkens, Hermann Schätzl, Raymond Bujdoso (2022) Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system Brain, Vol. 145, p. 3236-3249 Continue to DOI
Patrick Leven, Reiner Schneider, Kevin D. Siemens, Walker Jackson, Sven Wehner (2022) Application of a RiboTag-based approach to generate and analyze mRNA from enteric neural cells Neurogastroenterology and Motility, Vol. 34, Article e14309 Continue to DOI

2021

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguiere, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel (2021) CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Neurobiology of Disease, Vol. 158, Article 105473 Continue to DOI
Lech Kaczmarczyk, Nicole Reichenbach, Nelli Blank, Maria Jonson, Lars Dittrich, Gabor C. Petzold, Walker Jackson (2021) Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background Scientific Reports, Vol. 11, Article 5412 Continue to DOI

2020

Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger, Martin Fuhrmann (2020) Memory trace interference impairs recall in a mouse model of Alzheimer's disease Nature Neuroscience, Vol. 23, p. 952-958 Continue to DOI

2019

Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-ur Rahman, Wieslaw Krzyzak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Jackson (2019) Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice PLoS biology, Vol. 17, Article e3000374 Continue to DOI

2018

Cordula Rakers, Melvin Schleif, Nelli Blank, Hana Matušková, Thomas Ulas, Kristian Händler, Santiago Valle Torres, Toni Schumacher, Khalid Tai, Joachim L. Schultze, Walker S. Jackson, Gabor C. Petzold (2018) Stroke target identification guided by astrocyte transcriptome analysis Glia, Vol. 67, p. 619-633 Continue to DOI
Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen (2018) Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein Molecular Neurodegeneration, Vol. 13, Article 18 Continue to DOI
Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger (2018) Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, p. E2348-E2357 Continue to DOI

2017

Alana M. Thackray, Alzbeta Cardova, Hanna Wolf, Lydia Pradl, Ina Vorberg, Walker S. Jackson, Raymond Bujdoso (2017) Genetic human prion disease modelled in PrP transgenic Drosophila Biochemical Journal, Vol. 474, p. 3253-3267 Continue to DOI
Lars Dittrich, Alessandro Petese, Walker S Jackson (2017) The natural Disc1-deletion present in several inbred mouse strains does not affect sleep Scientific Reports, Vol. 7, Article 5665 Continue to DOI

2016

Lech Kaczmarczyk, Ylva Mende, Branko Zevnik, Walker S Jackson (2016) Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9 PLOS ONE, Vol. 11, Article e0154604 Continue to DOI

2013

Walker S Jackson, Andrew W Borkowski, Nicki E Watson, Oliver D King, Henryk Faas, Alan Jasanoff, Susan Lindquist (2013) Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, p. 14759-14764 Continue to DOI

Organisation