Selective Vulnerability to Neurodegenerative Diseases

We use mouse genetic tools to understand how specific brain regions are affected by neurodegenerative processes. 

We also are interested in understanding how poor sleep affects the onset and progression of neurodegenerative disease. We address these problems by developing models of diseases and tools to study them. One of our main technical focuses in recent years is to study how gene regulation in specific cell types is affected by neurodegenerative disease and sleep loss, using genetically encoded tools and next generation sequencing techniques. Manipulation of gene sequence and activity with CRISPR/Cas based methods is also a strength of the lab.


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