Selective Vulnerability to Neurodegenerative Diseases

We use mouse genetic tools to understand how specific brain regions are affected by neurodegenerative processes.

We also are interested in understanding how poor sleep affects the onset and progression of neurodegenerative disease. We address these problems by developing models of diseases and tools to study them. One of our main technical focuses in recent years is to study how gene regulation in specific cell types is affected by neurodegenerative disease and sleep loss, using genetically encoded tools and next generation sequencing techniques. Manipulation of gene sequence and activity with CRISPR/Cas based methods is also a strength of the lab.

 

News

Research

Publications

Publications in DiVA

2023

2022

2021

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguiere, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel (2021) CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Neurobiology of Disease, Vol. 158 Continue to DOI

2020

2019

2018

Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger (2018) Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, p. E2348-E2357 Continue to DOI

2017

2016

2013

Organisation