Fotografi av Walker Jackson

Walker Jackson

Universitetslektor

Jag studerar hur specifika regioner i hjärnan utsätts vid olika neurodegenerativa sjukdomar.

Selektiv sårbarhet för neurodegenerativa sjukdomar

Vi använder genetiska verktyg i musmodeller för att förstå hur specifika regioner i hjärnan påverkas av neurodegenerativa förlopp.

Vår grupp är också intresserad av att förstå hur sömnbrist påverkar neurodegenerativa sjukdomar både initialt och under sjukdomsförloppet. För att svara på våra frågeställningar utvecklar vi nya sjukdomsmodeller för att studera dessa fenomen. Med de tekniker vi använder har huvudfokus under senare år varit att studera hur genreglering i specifika celltyper påverkas av neurodegeneration och sömnbrist. För att undersöka detta använder vi genetiska verktyg och Next Generation Sequencing. Manipulation av gensekvenser och CRISPR/Cas-metoden är våra mest använda tekniker. 

 

Forskning

Publikationer

Publikationer i DiVA

2024

Daniel J. Walsh, Judy R. Rees, Surabhi Mehra, Matthew E. C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker Jackson, Joel C. Watts, Surachai Supattapone (2024) Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease PLoS Pathogens, Vol. 20, Artikel e1012087 Vidare till DOI
Walker Jackson, Susanne Bauer, Lech Kaczmarczyk, Srivathsa Magadi (2024) Selective Vulnerability to Neurodegenerative Disease: Insights from Cell Type-Specific Translatome Studies Biology, Vol. 13, Artikel 67 Vidare till DOI

2023

Sonia M. Vallabh, Dan Zou, Rose Pitstick, Jill OMoore, Janet Peters, Derek Silvius, Jasna Kriz, Walker Jackson, George A. Carlson, Eric Vallabh Minikel, Deborah E. Cabin (2023) Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease Journal of Virology, Vol. 97 Vidare till DOI
Maria I. Arifin, Lech Kaczmarczyk, Doris Zeng, Samia Hannaoui, Chi Lee, Sheng Chun Chang, Gordon Mitchell, Debbie McKenzie, Michael Beekes, Walker Jackson, Sabine Gilch (2023) Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Artikel e2221060120 Vidare till DOI
Hedayat Rahin, Walker Jackson, Magnus Thordstein (2023) Effect of Transcutaneous Spinal Direct Current Stimulation in Patients with Painful Polyneuropathy and Influence of Possible Predictors of Efficacy including BDNF Polymorphism: A Randomized, Sham-Controlled Crossover Study Brain Sciences, Vol. 13, Artikel 229 Vidare till DOI
Susanne Bauer, Chwen-Yu Chen, Maria Jonson, Lech Kaczmarczyk, Srivathsa Magadi, Walker Jackson (2023) Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntingtons disease mice Acta neuropathologica communications, Vol. 11, Artikel 17 Vidare till DOI
Walker Jackson (2023) Etiology matters: genetic and acquired prion diseases engage different mechanisms at a presymptomatic stage Neural Regeneration Research, Vol. 18, s. 2707-2708 Vidare till DOI

2022

Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhiannan H. Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J. Testaquadra, Stefan Bonn, Walker S. Jackson (2022) Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice PLoS Pathogens, Vol. 18, Artikel e1010747 Vidare till DOI
Susanne Bauer, Lars Dittrich, Lech Kaczmarczyk, Melvin Schleif, Rui Benfeitas, Walker Jackson (2022) Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons Life Science Alliance, Vol. 5, Artikel e202201530 Vidare till DOI
Alana M. Thackray, Brian Lam, Erin E. McNulty, Amy V Nalls, Candace K. Mathiason, Srivathsa Magadi, Walker Jackson, Olivier Andreoletti, Cristobal Marrero-Winkens, Hermann Schätzl, Raymond Bujdoso (2022) Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system Brain, Vol. 145, s. 3236-3249 Vidare till DOI
Patrick Leven, Reiner Schneider, Kevin D. Siemens, Walker Jackson, Sven Wehner (2022) Application of a RiboTag-based approach to generate and analyze mRNA from enteric neural cells Neurogastroenterology and Motility, Vol. 34, Artikel e14309 Vidare till DOI

2021

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguiere, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel (2021) CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Neurobiology of Disease, Vol. 158, Artikel 105473 Vidare till DOI
Lech Kaczmarczyk, Nicole Reichenbach, Nelli Blank, Maria Jonson, Lars Dittrich, Gabor C. Petzold, Walker Jackson (2021) Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background Scientific Reports, Vol. 11, Artikel 5412 Vidare till DOI

2020

Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger, Martin Fuhrmann (2020) Memory trace interference impairs recall in a mouse model of Alzheimer's disease Nature Neuroscience, Vol. 23, s. 952-958 Vidare till DOI

2019

Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-ur Rahman, Wieslaw Krzyzak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Jackson (2019) Tagger-A Swiss army knife for multiomics to dissect cell type-specific mechanisms of gene expression in mice PLoS biology, Vol. 17, Artikel e3000374 Vidare till DOI

2018

Cordula Rakers, Melvin Schleif, Nelli Blank, Hana Matušková, Thomas Ulas, Kristian Händler, Santiago Valle Torres, Toni Schumacher, Khalid Tai, Joachim L. Schultze, Walker S. Jackson, Gabor C. Petzold (2018) Stroke target identification guided by astrocyte transcriptome analysis Glia, Vol. 67, s. 619-633 Vidare till DOI
Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen (2018) Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein Molecular Neurodegeneration, Vol. 13, Artikel 18 Vidare till DOI
Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger (2018) Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, s. E2348-E2357 Vidare till DOI

2017

Alana M. Thackray, Alzbeta Cardova, Hanna Wolf, Lydia Pradl, Ina Vorberg, Walker S. Jackson, Raymond Bujdoso (2017) Genetic human prion disease modelled in PrP transgenic Drosophila Biochemical Journal, Vol. 474, s. 3253-3267 Vidare till DOI
Lars Dittrich, Alessandro Petese, Walker S Jackson (2017) The natural Disc1-deletion present in several inbred mouse strains does not affect sleep Scientific Reports, Vol. 7, Artikel 5665 Vidare till DOI

Nyheter