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Wen Zhong

Assistant Professor, Docent

My research mainly focuses on the integration of multi-omics, the interplay between genetics and phenotypes, and the development of data-driven strategies/tools for precision medicine.

Research Interests:

My research mainly focuses on the integration of multi-omics, the interplay between genetics and phenotypes, and the development of data-driven strategies/tools for precision medicine. The aim is to investigate the molecular biomarkers for the estimation of disease risks, early diagnosis of disease, stratification of drug treatment response, disease progression monitoring and the stratification of patients.

Publications

2023

Zhuo Ma, Xiaofei Zhang, Wen Zhong, Hongyan Yi, Xiaowei Chen, Yinsuo Zhao, Yanlin Ma, Eli Song, Tao Xu (2023) Deciphering early human pancreas development at the single-cell level Nature Communications, Vol. 14, Article 5354 Continue to DOI
Maria Bueno Alvez, Fredrik Edfors, Kalle von Feilitzen, Martin Zwahlen, Adil Mardinoglu, Per-Henrik Edqvist, Tobias Sjoblom, Emma Lundin, Natallia Rameika, Gunilla Enblad, Henrik Lindman, Martin Hoglund, Goran Hesselager, Karin Stalberg, Malin Enblad, Oscar E. Simonson, Michael Haggman, Tomas Axelsson, Mikael Aberg, Jessica Nordlund, Wen Zhong, Max Karlsson, Ulf Gyllensten, Fredrik Ponten, Linn Fagerberg, Mathias Uhlen (2023) Next generation pan-cancer blood proteome profiling using proximity extension assay Nature Communications, Vol. 14 Continue to DOI
Wen Zhong, Hanna Danielsson, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Anders K. Nilsson, Linn Fagerberg, Mathias Uhlen, Ann Hellstrom (2023) The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern Communications Medicine, Vol. 3, Article 107 Continue to DOI

2022

Wen Zhong, Swapnali Barde, Nicholas Mitsios, Csaba Adori, Per Oksvold, Kalle von Feilitzen, Liam O’Leary, László Csiba, Tibor Hortobágyi, Péter Szocsics, Naguib Mechawar, Zsófia Maglóczky, Éva Renner, Miklós Palkovits, Mathias Uhlén, Jan Mulder, Tomas Hökfelt (2022) The neuropeptide landscape of human prefrontal cortex Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Article e2123146119 Continue to DOI

2021

Wen Zhong, Fredrik Edfors, Anders Gummesson, Goeran Bergstroem, Linn Fagerberg, Mathias Uhlén (2021) Next generation plasma proteome profiling to monitor health and disease Nature Communications, Vol. 12, Article 2493 Continue to DOI

Selected publications

See full list in Google Scholar: https://scholar.google.com/citations?user=c7w5Bh4AAAAJ&hl=en

  1. Zhong W, Barde S, Mitsios N, Adori C, Oksvold P, Feilitzen K.V, O’Leary L, Csiba L, Hortobágyi T, Szocsics P and Mechawar N, Maglóczky Z, Renner E, Palkovits M, Uhlen M, Mulder J, Hökfelt T. (2022). The neuropeptide landscape of human prefrontal cortex. Proceedings of the National Academy of Sciences, 119(33), p.e2123146119.
    https://www.pnas.org/doi/abs/10.1073/pnas.2123146119
  2. Zhong W, Altay O, Arif M, Edfors F, Mardinoglu A, Uhlén M, Fagerberg L. (2021). Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms. EBioMedicine 74, 103723
    https://www.sciencedirect.com/science/article/pii/S235239642100517X
  3. Zhong W, Edfors F, Gummesson A, Bergstrom G, Fagerberg L, Uhlén M. (2021). Next generation plasma proteome profiling to monitor health and disease. Nature communications 12 (1), 1-12
    https://www.nature.com/articles/s41467-021-22767-z
  4. Karlsson MJ, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzon K, Zwahlen M, Muhammad A, Altay O, Li X, Ozcan M, Mardonoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlen M, Lindskog C. (2021). A single–cell type transcriptomics map of human tissues. Science Advances, 7(31), p.eabh2169.
    https://www.science.org/doi/10.1126/sciadv.abh2169
  5. Zhong W, Danielsson H, Tebani A, Karlsson MJ, Elfvin A., Hellgren, G., Brusselaers, N., Brodin, P., Hellström, A., Fagerberg, L., Uhlén, M., (2021). Dramatic changes in blood protein levels during the first week of life in extremely preterm infants. Pediatric research, 89(3), pp.604-612.
    https://www.nature.com/articles/s41390-020-0912-8
  6. Zhong W, Gummesson A, Tebani A, Karlsson M J, Hong MG, Schwenk JM, Edfors F, Bergström G, Fagerberg L, Uhlén M. (2020). Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort. Genome Medicine, 12(1), 1-16.
    https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00755-0
  7. Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, Karlsson MJ, Arif M, Dodig-Crnković T, Mardinoglu A, Lee S, Zhang C, Chen Y, Olin A, Mikes J, Danielsson H, von Feilitzen K, Jansson PA, Angerås O, Huss M, Kjellqvist S, Odeberg J, Edfors F, Tremaroli V, Forsström B, Schwenk JM, Nilsson P, Moritz T, Bäckhed F, Engstrand L, Brodin P, Bergström G, Uhlén M, Fagerberg L. (2020). Integration of molecular profiles in a longitudinal wellness profiling cohort. Nature communications, 11(1), 1-14.
    https://www.nature.com/articles/s41467-020-18148-7
  8. Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J. (2020). An atlas of the protein-coding genes in the human, pig, and mouse brain. Science, 367 (6482)
    https://www.science.org/doi/10.1126/science.aay5947
  9. Uhlén M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P. (2019). A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science, 366 (6472)
    https://www.science.org/doi/10.1126/science.aax9198
  10. Hou J#, Li Z#, Zhong W#, Hao Q, Lei L, Wang L, Zhao D, Xu P, Zhou Y, Wang Y, Xu T. (2017). Temporal transcriptomic and proteomic landscapes of deteriorating pancreatic islets in type 2 diabetic rats. Diabetes, 66(8), 2188-2200 (# equal contribution)
    https://diabetes.diabetesjournals.org/content/66/8/2188

News

Image of Wen Zhong at Campus US.

Understanding the neuropeptide systems in human prefrontal cortex

Wen Zhong, new DDLS Fellow at LiU, has been involved in a study connected to the Human Protein Atlas. The international collaborative study’s finding will contribute to identify novel therapeutic strategies of relevance for human brain disorders.
Wen Zhong

The first DDLS Fellow at LiU is recruiting

Wen Zhong is the first DDLS Fellow that has been recruited to LiU. With the help of a postdoctoral fellowship she is now expanding her research group. “We welcome a creative, self-motivated, and proactive team-player to join the research team.”

Organisation

Teaser image for the division CELLB at BKV.

Division of Cell Biology (CELLB)

The main research focus of the Division of Cell Biology is to understand the construction and function of cells.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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