Photo of Wen Zhong

Wen Zhong

Assistant Professor, Docent

My research mainly focuses on the integration of multi-omics, the interplay between genetics and phenotypes, and the development of data-driven strategies/tools for precision medicine.

Research Interests:

My research mainly focuses on the integration of multi-omics, the interplay between genetics and phenotypes, and the development of data-driven strategies/tools for precision medicine. The aim is to investigate the molecular biomarkers for the estimation of disease risks, early diagnosis of disease, stratification of drug treatment response, disease progression monitoring and the stratification of patients.

Publications

2026

Pia Lundgren, Hanna Danielsson, Mohit B. Panwar, Maria Bueno Alvez, Aldina Pivodic, Wen Zhong, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Susanna Klevebro, Anders K. Nilsson, Zhongjie Fu, Lois E. H. Smith, Mathias Uhlen, Ann Hellstrom (2026) Proteomic Profile in Retinopathy of Prematurity: A Secondary Analysis of the Mega Donna Mega Randomized Clinical Trial JAMA ophthalmology (Article in journal) Continue to DOI

2025

Xingyue Wang, Xiangyu Qiao, Alberto Zenere, Swapnali Barde, Jing Wang, Wen Zhong (2025) HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations Genome Biology, Vol. 27, Article 7 (Article in journal) Continue to DOI
Maria Bueno Alvez, Sofia Bergstrom, Josefin Kenrick, Emil Johansson, Mikael Aberg, Murat Akyildiz, Ozlem Altay, Hilda Skold, Konstantinos Antonopoulos, Emmanouil Apostolakis, Yasin Hasan Balcioglu, Anna Bergstrom, Goran Bergstrom, Sophia Bjorkander, Suzanne Egyhazi Brage, Petter Brodin, Lynn Butler, Sara Cajander, Hanna Danielsson, Murat Dayangac, Gizem Dinler-Doganay, Levent Doganay, Gunilla Enblad, Malin Enblad, Linn Fagerberg, Sara Falck-Jones, Anna Farnert, Mattias Forsberg, Laura Gonzalez, Anders Gummesson, Karin Gunnarsson, Iva Gunnarsson, Ulf Gyllensten, Goran Hesselager, Andreas Hober, Martin Hoglund, Marie Holmqvist, Begum Horuluoglu, Rebecka Hultgren, Maria Jesus Iglesias, Helena Janols, Fredric Johansson, Anette Johnsson, Lars Klareskog, David Kotol, Inger Kull, Marika Kvarnstrom, Maximilian Julius Lautenbach, Ulrika Liljedahl, Henrik Lindman, Cecilia Lindskog, Miklos Lipcsey, Ingrid E. Lundberg, Adil Mardinoglu, Erik Melen, Lingqi Meng, Anne-Sophie Merritt, Jan Mulder, Mai Thi-Huyen Nguyen, Jessica Nordlund, Anna Norrby-Teglund, Antonella Notarnicola, Piotr Nowak, Jacob Odeberg, Per Oksvold, Tomas Olsson, Leonid Padyukov, Karlis Pauksens, Fredrik Piehl, Elisa Pin, Fredrik Ponten, Natallia Rameika, Anton Reepalu, Joy Roy, Jochen M. Schwenk, Meltem Sen, Antti Siika, Oscar E. Simonson, Asa Sivertsson, Tobias Sjoblom, Evelina Sjostedt, Lovisa Skoglund, Anna Smed-Sorensen, Klara Sonden, Anders Sonnerborg, Karin Stalberg, Kristoffer Stralin, Jonas Sunden-Cullberg, Christopher Sundling, Thanadol Sutantiwanichkul, Fernanda Costa Svedman, Mattias Svensson, Elisabet Svenungsson, Tadepally Lakshmikanth, Khue Hua Tran-Minh, Hasan Turkez, Christian Unge, Per Venge, Marie Wahren-Herlenius, Jakob Woessmann, Hong Yang, Umit Haluk Yesilkaya, Meng Yuan, Mujdat Zeybel, Cheng Zhang, Wen Zhong, Martin Zwahlen, Kalle Von Feilitzen, Peter Nilsson, Fredrik Edfors, Mathias Uhlen (2025) A human pan-disease blood atlas of the circulating proteome Science, Vol. 390, Article eadx2678 (Article in journal) Continue to DOI
Ziyang Tan, Wen Zhong, Hanna Danielsson, Aron Arzoomand, Tadepally Lakshmikanth, Qi Chen, Jaromir Mikes, Jun Wang, Yang Chen, Anna James, Anders K. Nilsson, Anders Elfvin, Nele Brusselaers, Theo Portlock, Pia Lundgren, Karin Savman, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Mathias Uhlen, Ann Hellstrom, Petter Brodin (2025) Immune development differs between preterm newborns fed mothers' own milk and donor milk iScience, Vol. 28, Article 112918 (Article in journal) Continue to DOI
Jing Wang, Alberto Zenere, Xingyue Wang, Goeran Bergstrom, Fredrik Edfors, Mathias Uhlen, Wen Zhong (2025) Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health Genome Medicine, Vol. 17, Article 68 (Article in journal) Continue to DOI

Selected publications

See full list in Google Scholar: https://scholar.google.com/citations?user=c7w5Bh4AAAAJ&hl=en

  1. Zhong W, Barde S, Mitsios N, Adori C, Oksvold P, Feilitzen K.V, O’Leary L, Csiba L, Hortobágyi T, Szocsics P and Mechawar N, Maglóczky Z, Renner E, Palkovits M, Uhlen M, Mulder J, Hökfelt T. (2022). The neuropeptide landscape of human prefrontal cortex. Proceedings of the National Academy of Sciences, 119(33), p.e2123146119.
    https://www.pnas.org/doi/abs/10.1073/pnas.2123146119
  2. Zhong W, Altay O, Arif M, Edfors F, Mardinoglu A, Uhlén M, Fagerberg L. (2021). Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms. EBioMedicine 74, 103723
    https://www.sciencedirect.com/science/article/pii/S235239642100517X
  3. Zhong W, Edfors F, Gummesson A, Bergstrom G, Fagerberg L, Uhlén M. (2021). Next generation plasma proteome profiling to monitor health and disease. Nature communications 12 (1), 1-12
    https://www.nature.com/articles/s41467-021-22767-z
  4. Karlsson MJ, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzon K, Zwahlen M, Muhammad A, Altay O, Li X, Ozcan M, Mardonoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlen M, Lindskog C. (2021). A single–cell type transcriptomics map of human tissues. Science Advances, 7(31), p.eabh2169.
    https://www.science.org/doi/10.1126/sciadv.abh2169
  5. Zhong W, Danielsson H, Tebani A, Karlsson MJ, Elfvin A., Hellgren, G., Brusselaers, N., Brodin, P., Hellström, A., Fagerberg, L., Uhlén, M., (2021). Dramatic changes in blood protein levels during the first week of life in extremely preterm infants. Pediatric research, 89(3), pp.604-612.
    https://www.nature.com/articles/s41390-020-0912-8
  6. Zhong W, Gummesson A, Tebani A, Karlsson M J, Hong MG, Schwenk JM, Edfors F, Bergström G, Fagerberg L, Uhlén M. (2020). Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort. Genome Medicine, 12(1), 1-16.
    https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00755-0
  7. Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, Karlsson MJ, Arif M, Dodig-Crnković T, Mardinoglu A, Lee S, Zhang C, Chen Y, Olin A, Mikes J, Danielsson H, von Feilitzen K, Jansson PA, Angerås O, Huss M, Kjellqvist S, Odeberg J, Edfors F, Tremaroli V, Forsström B, Schwenk JM, Nilsson P, Moritz T, Bäckhed F, Engstrand L, Brodin P, Bergström G, Uhlén M, Fagerberg L. (2020). Integration of molecular profiles in a longitudinal wellness profiling cohort. Nature communications, 11(1), 1-14.
    https://www.nature.com/articles/s41467-020-18148-7
  8. Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J. (2020). An atlas of the protein-coding genes in the human, pig, and mouse brain. Science, 367 (6482)
    https://www.science.org/doi/10.1126/science.aay5947
  9. Uhlén M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P. (2019). A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science, 366 (6472)
    https://www.science.org/doi/10.1126/science.aax9198
  10. Hou J#, Li Z#, Zhong W#, Hao Q, Lei L, Wang L, Zhao D, Xu P, Zhou Y, Wang Y, Xu T. (2017). Temporal transcriptomic and proteomic landscapes of deteriorating pancreatic islets in type 2 diabetic rats. Diabetes, 66(8), 2188-2200 (# equal contribution)
    https://diabetes.diabetesjournals.org/content/66/8/2188

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