Neurointensive care monitoring 

Neuro intensive care instruments

The neurointensive care unit (NICU) is highly specialized in monitoring severe brain damages such as traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Cerebral blood flow (CBF) is therefore a parameter of outmost importance to record in NICU. Our specific interest is in cerebral microcirculation parameters monitored with optical techniques and their comparison with conventionally monitored circulatory indicators, Xe-CT, perfusion MRI and microdialysis. The aim of this multiparametric approach is to investigate the possibility to detect vasospasm, progressing into ischemia and brain infarction, and secondary bleedings in brain trauma at an early stage.

Laser Doppler flowmetry and cerebral microcirculation

Cerebral microcirculation can be measured with laser Doppler flowmetry (LDF). Low power laser light is transmitted through an optical fiber to the tissue. In 2005 we introduced LDF in brain surgery in relation to deep brain stimulation (DBS) implantation. We have now adapted LDF to long term monitoring of cerebral perfusion in NICU.

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Key publications

Rejmstad P, Haj-Hosseini N, Åneman O, Wårdell K. Optical monitoring of cerebral microcirculation in neurointensive care, Med & Biol Eng & Comp, Vol 56 (7), pp 1201–1210, 2018.

Zsigmond P., Hemm-Ode S., Wårdell K. Optical Measurements during Deep Brain Stimulation Lead Implantation: Safety Aspects , Stereotact Funct Neurosurg., 95(6):392-399, 2018.

Wårdell K, Zsigmond P, Richter J, Hemm S Optical Guidance System for Deep Brain Stimulation Surgery – from Experimental Studies to Clinical Use, OSA, Biophotonics Conference, Florida, USA, 2018.

Peter Rejmstad, Optical Monitoring of Cerebral Microcirculation , Linköping studies in Science and Technology, Doctorate Thesis No. 1807, 2017, ISBN 0345-7524

Wårdell K, Optical Techniques for Navigation during in Stereotactic Neurosurgery, Sensors and Materials, Vol. 28, No. 10, 1105–1116, 2016.

Rejmstad P, Åkesson G, Åneman O, Wårdell K, A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery, Medical & Biological Engineering & Computing, 54:123–131, 2016.

Wårdell K, Zsigmond P, Richter J, Hemm S Relationship between laser Doppler signals and anatomy during deep brain stimulation electrode implantation toward the ventral intermediate nucleus and subthalamic nucleus. Neurosurgery, Jun;72(2 Suppl Operative):ons127-40; disc. ons140, 2013.

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List of all of the Neuroengineering group publications.

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