TPMT nomenclature committee (TPMT Alleles)

Welcome to the Thiopurine methyltransferase (TPMT) nomenclature website

This site has initially been set up by Dr Malin Lindqvist Appell, Linkoping University, Sweden and Dr Sally Coulthard, Newcastle University, UK. We are thankful to the advisory board for fruitful discussions during the development of the website.

Outlined below is the aim and intended scope of the website. We welcome and encourage any comments from researchers in the field to improve the website. A paper was published in 2013 describing the work of the TPMT nomenclature committee (Appell ML et al., 2013 Pharmacogenetics and Genomics 2013, 23:242-248).

The website will be continuously updated with novel alleles and information regarding these.


To maintain a common, logical nomenclature system for thiopurine methyltransferase (TPMT) alleles in humans.

Authors are encouraged to submit novel TPMT alleles (sequence and functionality if available) preferably before publication to the website for confidential designation and reservation of a novel allele name by the nomenclature committee. We will aim to continue the current style of nomenclature to avoid any confusion in the future.

/Nomenclature committee members

Table of TPMT alleles

The table defines all the single-nucleotide polymorphisms (SNPs) in TPMT as of Nov 2022.

Inclusion criteria

The main function of this Web page is to encourage scientists worldwide to speak the same language and to avoid "home-made" allelic designations that can confuse the nomenclature system and the scientific literature, and it contains the recommended nomenclature for the human polymorphic TPMT gene. It adheres to the guidelines provided in Antonarakis and the Nomenclature Working Group (1998) and den Dunnen and Antonarakis (2001) as detailed on the page below:

TPMT inclusion criteria

Submit a novel TPMT SNP

Editor & Advisory Board


Advisory Board

Jonathan Berg
John Duley
William Evans
Martin Kennedy
Lynne Lennard
Tony Marinaki
Howard McLeod
Mary Relling
Elke Schaeffeler
Matthias Schwab
Richard Weinshilboum
Allen Yeoh