Vaccination against infectious diseases is one of the most powerful prophylactic measures to reduce morbidity and mortality.
Not only will we need new vaccine products (i.e DNA-vaccines, Viral vectors, recombinant proteins), we should also consider how vaccines should be administered, instead of by syringe and needles (as most often today).
Since most of our infectious disease-causing agents infect us by mucosal routes, and our vaccines most often do not stimulate immune responses in the mucosal tissues, we support the idea of developing vaccination procedures that could be used to elicit both mucosal and systemic immunity against the infectious microorganisms. Some vaccine products are also too weak as immunogens by themselves to provide efficient immunity. In these cases, they may benefit by the use of vaccine-adjuvant combinations that stimulate immune responses.
Our work is thus focused on how to provide neutralizing antibodies, long-lasting memory B- and T-lymphocytes in mucosal tissues and lymphoid tissues against pathogenic microorganisms.