Photo of Anna Spångeus

Anna Spångeus

Senior Associate Professor

I am associate professor and senior consultant in internal medicine/endocrinology. My research mainly concerns bone health and the prevention of osteoporosis fractures.

Osteoporosis - Skeletal failure

Osteoporosis implies that the skeleton fails to fulfil their normal function to withstand a certain load/violence and can fracture even at low-energy trauma, so-called osteoporosis fracture. Today, bone health is measured with a so-called Dual energy X-ray Absorptiometry (DXA) where a bone density is obtained. In addition, qualitative measurements, such as trabecular and cortical properties could add valuable information on patient’s bone health and future fracture risk.  This is, however, not possible in a clinical routine setting today. 

Osteoporosis fractures are common, costly and serious both regarding excess mortality and a risk of lifelong pain and permanent disabilities. At the same time, the disease is currently underdiagnosed and undertreated both regarding pharmacological and non-pharmacological treatment. Fracture Liaison Services (FLS) are built to secure the identification and treatment of risk individuals for osteoporosis. New innovative pathways are important to improve and secure these FLS to ensure that these risk patients are correctly identified, diagnosed and treated optimally from a holistic perspective.

In our research, we look at several links in the FLS, both in terms of identification/diagnostics (new radiological techniques and clinical flows) as well as treatment (drug compliance, patient education and training). 


About me


  • Senior consultant (2021)
  • Associate Professor (2020)
  • Senior Lecturer (2012)
  • Specialist internal medicine (2012) and endocrinology and diabetology (2014)
  • Post-doc Imperial College, London, UK (2005/2006)
  • MD (2005)
  • PhD (1999)

Field of Teaching

  • Medical programme: Lectures/seminars in calcium disorders and osteoporosis
  • Medical programme: Former Chair of the Tema CREN (courses 2, 3, 6 and 7), until 2020.


  • Head of Research NSC from 2021
  • Vice Chairman of the Council for Patient and Resident Participation fr.o.m. HT 21
  • Member of the Research Council fr.o.m. HT21
  • Supervisor 1 PhD-student (internal medicine/endocrinology, finished 2020)
  • Co-supervisor 5 PhD students (3 ongoing, 2 finished 2012 and 2010, respectively)
  • Kandidate Kork Prize 2020
  • Andreas Rousseau's Prize 2020 ("best lecture of the year at the medical programme")


Cover of publication ''
Emese Toth, Jonas Banefelt, Kristina Akesson, Anna Spångeus, Gustaf Ortsater, Cesar Libanati (2020)

Journal of Bone and Mineral Research , Vol.35 , s.861-868 Continue to DOI

Cover of publication ''
J. Banefelt, K. E. Akesson, Anna Spångeus, O. Ljunggren, L. Karlsson, O. Strom, G. Ortsater, C. Libanati, E. Toth (2019)

Osteoporosis International , Vol.30 , s.601-609 Continue to DOI

Cover of publication ''
Anna Spångeus, Simon Johansson, Mischa Woisetschläger (2020)



Anna Spångeus, Johan Rydetun, Mischa Woisetschläger (2024) Prevalence of denosumab-induced hypocalcemia: a retrospective observational study of patients routinely monitored with ionized calcium post-injection Osteoporosis International, Vol. 35, p. 173-180 Continue to DOI


Hans Arnqvist, Per Leandersson, Anna Spångeus (2023) Vitamin D status in longstanding type 1 diabetes and controls. Association with upper extremity impairments Upsala Journal of Medical Sciences, Vol. 128 Continue to DOI
Anna Spångeus, Catrin Willerton, Paul Enthoven, Ann-Charlotte Grahn Kronhed (2023) Patient Education Improves Pain and Health-Related Quality of Life in Patients with Established Spinal Osteoporosis in Primary Care-A Pilot Study of Short- and Long-Term Effects International Journal of Environmental Research and Public Health, Vol. 20, Article 4933 Continue to DOI
Eva Klintström, Benjamin Klintström, Anna Spångeus, Michael Sandborg, Mischa Woisetschläger (2023) Trabecular bone microstructure analysis on data from a novel twin robotic X-ray device Acta Radiologica, Vol. 64, p. 1566-1572 Continue to DOI
Ann-Charlotte Grahn Kronhed, Paul Enthoven, Catrin Willerton, Martin Andersson, Joakim Baardh, Anna Spångeus (2023) Experiences of participating in a structured osteoporosis school in persons with established spinal osteoporosis - an interview study European Journal of Physiotherapy Continue to DOI