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Charalampos Georgiopoulos

My research concerns impaired olfaction in parkinsonian syndromes

Impaired olfaction in parkinsonian syndromes

Olfactory dysfunction is one of the most common premotor symptoms in Parkinson’s Disease. With help of various imaging modalities, such as Magnetic Resonance Imaging, we can visualize the affected brain areas and detect potential differences between parkinsonian patients and healthy individuals. 

Olfactory loss in Parkinson’s disease was reported for the first time in 1975 and a lot of research has since then been conducted on this field. Apart from Parkinson’s disease, there are other neurodegenerative disorders that share similar symptoms, but differ on pathological, clinical and genetic grounds (i.e. Lewy body disease, Multiple System Atrophy and Progressive Supranuclear Palsy). The differential diagnosis among these disorders can often be challenging. In my PhD-studies, I focus on how different imaging modalities can help us understand the underlying mechanism behind olfactory loss and how olfactory dysfunction can be a diagnostic tool.  

In my first article, I compared the diagnostic accuracy of DaT SPECT and ordinary olfactory testing. SPECT stands for Single Photon Emission Computed Tomography, and DaT SPECT is a validated method in diagnosing Parkinsonian syndromes. The main findings of this study show that DaT SPECT has a higher predictive value than ordinary olfactory testing, but the combination of these two methods can increase the diagnostic accuracy. 

DaT SPECTI am currently working with three different applications of Magnetic Resonance Imaging (MRI). Functional MRI can help us detect differences in the activation pattern of olfactory cortex. Moreover, with help of Diffusion Tensor Imaging, we can discover potential variations in the olfactory tract between parkinsonian patients. At last, Magnetization Transfer Ratio can identify changes in grey and white matter in Parkinson’s Disease.

fMRI

Besides my doctoral studies, I am a resident in Radiology at Linköping University Hospital and I plan to be specialized in Neuroradiology.

Publications

2024

Gustav Magnusson, Maria Engström, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Anders Tisell (2024) High inspired CO<sub>2</sub> target accuracy in mechanical ventilation and spontaneous breathing using the Additional CO<sub>2</sub> method Frontiers in Medicine, Vol. 11, Article 1352012 (Article in journal) Continue to DOI
Xiaoguang Yan, Hakim Benkhatar, Yun-Ting Chao, Charalampos Georgiopoulos, Thomas Hummel (2024) Anterior Skull Base Abnormalities in Congenital Anosmia Journal for Oto-Rhino-Laryngology, Vol. 86, p. 1-12 (Article in journal) Continue to DOI

2023

Tom Eek, Fredrik Lundin, Maria Larsson, Paul Hamilton, Charalampos Georgiopoulos (2023) Neural suppression in odor recognition memory Chemical Senses, Vol. 48, Article bjad001 (Article in journal) Continue to DOI

2022

Divesh Thaploo, Akshita Joshi, Charalampos Georgiopoulos, Jonathan Warr, Thomas Hummel (2022) Tractography indicates lateralized differences between trigeminal and olfactory pathways NeuroImage, Vol. 261, Article 119518 (Article in journal) Continue to DOI
Divesh Thaploo, Charalampos Georgiopoulos, Antje Haehner, Thomas Hummel (2022) Subtle Differences in Brain Architecture in Patients with Congenital Anosmia Brain Topography, Vol. 35, p. 337-340 (Article in journal) Continue to DOI

Publications

2024

Gustav Magnusson, Maria Engström, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Anders Tisell (2024) High inspired CO<sub>2</sub> target accuracy in mechanical ventilation and spontaneous breathing using the Additional CO<sub>2</sub> method Frontiers in Medicine, Vol. 11, Article 1352012 (Article in journal) Continue to DOI
Xiaoguang Yan, Hakim Benkhatar, Yun-Ting Chao, Charalampos Georgiopoulos, Thomas Hummel (2024) Anterior Skull Base Abnormalities in Congenital Anosmia Journal for Oto-Rhino-Laryngology, Vol. 86, p. 1-12 (Article in journal) Continue to DOI

2023

Tom Eek, Fredrik Lundin, Maria Larsson, Paul Hamilton, Charalampos Georgiopoulos (2023) Neural suppression in odor recognition memory Chemical Senses, Vol. 48, Article bjad001 (Article in journal) Continue to DOI

About me

CV

  • Medical degree 2008, Univeristy of Athens
  • MSc in Biomedical Engineering 2010, Univeristy of Patras
  • PhD student since 2013

Organisation