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Stefan Koch

Senior Associate Professor

I am investigating how cellular signaling shapes tissue injury and repair
in inflammatory disorders and cancer

Molecular cell signaling

How do cells communicate with each other, and how can we interfere with their communication to cure common diseases?

Every cell in our body constantly makes decisions based on exchange of information with its surroundings. For example, cells next to a wound will actively repair the tissue and then return to a resting state. Bad decisions, on the other hand, are the cause of many common diseases, such as auto-immune disorders.

My group seeks to understand the molecular foundations of the complex signaling networks within cells, with the goal to find new treatment options for inflammatory diseases and cancer.


Publications

2024

Giulia Pizzolato, Lavanya Moparthi, Pierfrancesco Pagella, Claudio Cantù, Padraig D´arcy, Stefan Koch (2024) The tumour suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1 Journal of Biological Chemistry, Vol. 300, Article 107126 (Article in journal) Continue to DOI
Diana Atanasova, Ekaterina Mirgorodskaya, Lavanya Moparthi, Stefan Koch, Mathias Haarhaus, Sonoko Narisawa, José Luis Millán, Eva Landberg, Per Magnusson (2024) Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts JBMR Plus, Vol. 8, Article ziae006 (Article in journal) Continue to DOI
Archana Bhardwaj, Andreas Münch, Julia Montague, Stefan Koch, Philip Rosenstiel, Celia Escudero-Hernández (2024) Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis United European Gastroenterology journal (Article in journal) Continue to DOI

2023

Lavanya Moparthi, Stefan Koch (2023) FOX transcription factors are common regulators of Wnt/beta- catenin-dependent gene transcription Journal of Biological Chemistry, Vol. 299, Article 104667 (Article in journal) Continue to DOI

2022

Giulia Pizzolato, Lavanya Moparthi, Simon Söderholm, Claudio Cantù, Stefan Koch (2022) The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes. Journal of Cell Science, Vol. 135, Article jcs260082 (Article in journal) Continue to DOI

Publications

2024

Giulia Pizzolato, Lavanya Moparthi, Pierfrancesco Pagella, Claudio Cantù, Padraig D´arcy, Stefan Koch (2024) The tumour suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1 Journal of Biological Chemistry, Vol. 300, Article 107126 (Article in journal) Continue to DOI
Diana Atanasova, Ekaterina Mirgorodskaya, Lavanya Moparthi, Stefan Koch, Mathias Haarhaus, Sonoko Narisawa, José Luis Millán, Eva Landberg, Per Magnusson (2024) Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts JBMR Plus, Vol. 8, Article ziae006 (Article in journal) Continue to DOI
Archana Bhardwaj, Andreas Münch, Julia Montague, Stefan Koch, Philip Rosenstiel, Celia Escudero-Hernández (2024) Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis United European Gastroenterology journal (Article in journal) Continue to DOI

Research

Cell signaling in inflammation and cancer.

Cell signaling in intestinal inflammation

All cells in an organism communicate with one another and with their environment through integrated signaling pathways. By exploring the molecular events that shape cellular decision-making, we can predict and control the fate of individual cells.

Related research

Cell and Molecular Biology

Molecular Biology research focus on  how molecules and systems within cells interact. Of special interest is the flow of genetic information from DNA via RNA to protein synthesis, and how these processes are regulated.
Image of molecules that will take you to WCMM's homepage.

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Organisation

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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