Brain-gut interactions in IBS. Integration of peripheral and central pathophysiology

Irritable bowel syndrome (IBS) is a chronic disorder characterized by abdominal pain and alterations in bowel habits (diarrhea, constipation, or both in an alternating pattern). IBS is also associated with mental and physical comorbidity such as anxiety, depression, fatigue and other chronic pain syndromes. Despite advances in modern medicine, IBS remains a persistent, disabling, and costly problem.

IBS is a disorder of dysregulated brain–gut homeostasis involving peripheral and central mechanisms. An increasing body of evidence strongly supports both the role of peripheral factors such as disturbed microbiota composition, mucosal barrier or gut immune function but also altered brain function in IBS pathophysiology.

Together with national and international collaborators and a local team consisting of gastroenterologists, psychologists, physicists and biologist we aim to provide new data on microbiota- immune-CNS interactions in IBS pathophysiology. The overall aim of ours studies are linking together central and peripheral components of the brain-gut-microbiota axis.

Publications

Selected publications

Adriane Icenhour, Suzanne Witt, Sigrid Elsenbruch, Mats Lowén, Maria Engström, Kirsten Tillisch, Emeran A. Mayer, Susanna Walter (2017)

NeuroImage Continue to DOI

Mats Larsson, Kirsten Tillisch, Bud Craig, Maria Engström, Jennifer Labus, Bruce Naliboff, Peter Lundberg, Magnus Ström, Emeran Mayer, Susanna Walter (2012)

Gastroenterology Continue to DOI

Publications in DiVA

2018

Maria Henström, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Koeckritz-Blickwede, Louise B. Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E. Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simren, Pontus Karling, Bodil Ohlsson, Peter T. Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F. Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y. Naim, Mauro DAmato (2018) Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome Gut Continue to DOI