Our aim is to better understand the molecular underpinnings of autoimmune disease. At the same time, we are developing RNA therapeutics as new treatments for autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.
Research Projects
- mRNA regulation in B cells: We are working on understanding how nuclear condensates and cytoplasmic interactions affect the production of inflammatory molecules.
- Heterogeneity in adaptive immune disease: Using proximity labelling and high-throughput imaging approaches, we are characterizing cellular and autoantibody heterogeneity in patient and donor samples.
- RNA therapeutics for autoimmune disease: We are developing pre-clinical targeted approaches to reduce autoreactivity using short oligonucleotides and optimizing delivery to primary B cells.
For more information, see our website.
