I have, for the first time in the world, described diabetic heart metabolism during coronary surgery and use of myocardial protection with high-dose glucose - insulin - potassium in this context in my medical dissertation that I defended in 2001. (Diabetes and Coronary Surgery: Metabolic and clinical studies on diabetic patients after coronary surgery with special reference to cardiac metabolism and high-dose GIK)
I have changed my research focus after my PhD and have as a postdoctoral research fellow been working at the Dept of pharmacology with ischemia - reperfusion in isolated heart as well as cardiac tissue. At the same time I conducted a clinical microdyalisis study of the skeletal muscle metabolism under cardiac surgery. The main interest was directed towards the experimental study of myocardial perfusion using infrared technology. I have gradually developed cooperation with IEI Department of Thermic Research, Cardio-thoracic Surgery and CMIV to, for the first time in the world, use "augmented reality" to visualize experimental cardiac ischemia during experimental conditions similar to cardiac surgery. The collaboration with cardiac surgeons and IMT Department of Biomedical Engineering has led to opportunities to participate in experiments and clinical studies with NIRS (near infra-red radiation) to describe myocardial oxygenation.
Cooperation with the Department of Pharmacology has continued and was transformed to research with translational character which means the different clinical questions were taken to the lab and studied in experiments.
Ischemic preconditioningIn the present time my research focus is on the late effect of "ischemic preconditioning" projects done in collaboration with researchers at Clinical Physiology and Pharmacology in Linköping and the Department of Pharmacology in Szeged (Hungary), experimental research of renal oxygenation during cardiopulmonary bypass run in collaboration with the Department of Nephrology in Memphis (USA) and the levosimendan´s protective effect on the heart and the human arterial graft (experimental) in collaboration with the Department of Pharmacology in Linköping .
In addition to the above studies, I conduct clinical studies on the early postoperative diagnosis of kidney damage in cardiac surgery and pedagogic research on problem based learning.