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Haemostasis Research Group in Linköping

blood droplet in red microscope light
The formation of a blood clot is studied in microscope Photographer: Karin Söderlund Leifler

The Haemostasis Research Group at LiU is led by Professor Tomas L. Lindahl. There are three postdocs, two PhD students and two technical personnel in the group.

We study regulation of platelet activation and interaction with coagulation- from biochemistry and genes to clinical studies on antithrombotic drugs in cardiovascular diseases and how covid-19 causes thrombosis. Furthermore, we develop new diagnostic methods.

The group has collaborations with several clinical researchers at the University Hospital in Linköping, biotechnology companies and research laboratories in Norway, England and Australia.

You can find more information about our research group via this website: platelets.se.

Group members

Principal investigator

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Tomas Lindahl

Professor Emeritus

Members

Kerstin Arbring

PhD student

Walaa Bader

Niklas Boknäs
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Margareta Holmström

Senior Associate Professor, Head of Division, Head of Unit

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Tomas Lindahl

Professor Emeritus

Mikael Lund

PhD student

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Ankit Macwan

Principal Research Engineer

Leila Shabani Mashcool

PhD student

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Kjersti Tunströmer

Principal Research Engineer

Selected publications

1. Hillarp A, Strandberg K, Gustafsson KM, Lindahl TL. Unveiling the complex effects of direct oral anticoagulants on dilute Russell's viper venom time assays. J Thromb Haemost. 2020 Apr 15. doi: 10.1111/jth.14829. Online ahead of print.

2. Macwan AS, Boknäs N, Ntzouni MP, Ramström S, Gibbins JM, Faxälv L, Lindahl TL. Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica, 2019;104:1482-1492.

3. Alfredsson J, Swahn E, Gustafsson KM, Janzon M, Jonasson L, Logander E, Nilsson L, Lindahl TL. Individual long-term variation of platelet reactivity in patients with dual antiplatelet therapy after myocardial infarction. Platelets. 2019;30:572-8.

4. Heenkenda MK, Lindahl TL, Osman A. Frequency of Ala120Thr PAR4 variant varies widely across Sub-Saharan African populations. Blood. 2018;132:2103-6.

5. Tunströmer K, Faxälv L, Boknäs N, Lindahl TL. Quantification of Platelet Contractile Movements during Thrombus Formation. Thromb Haemost. 2018;118:1600-11.

6. Hillarp A, Strandberg K, Baghaei F, Fagerberg Blixter I, Gustafsson KM, Lindahl TL. Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays. Scand J Clin Lab Invest. 2018 Nov - Dec;78(7-8):575-583.

7. Boknäs N, Ramström S, Faxälv L, Lindahl TL. Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders. Platelets. 2018 Jul;29(5):512-519.

8. Sánchez Centellas D, Gudlur S, Vicente-Carrillo A, Ramström S, Lindahl TL. A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets. Thromb Res. 2017;154:84-92.

9. Boknäs N, Faxälv L, Sanchez Centellas D, Wallstedt M, Ramström S, Grenegård M, Lindahl TL. Thrombin-induced platelet activation via PAR4: pivotal role for exosite II. Thromb Haemost. 2014;112:558-65.

10. Boknäs N, Faxälv L, Ström JO, Tengvall P, Theodorsson E, Ramström S, Lindahl TL. Response: Platelets do not generate activated factor XII--how inappropriate experimental models have led to misleading conclusions. Blood. 2014;124:1692-4.


News

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A view into a blood clot

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Organisation

Division of Clinical Chemistry and Pharmacology (KKF)

The Division of Clinical Chemistry and Pharmacology (KKF) conducts research and education that includes the subject areas of anesthesiology/intensive care, pharmacology and clinical pharmacology, forensic sciences and clinical chemistry.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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