Haemostasis Research Group in Linköping

blood droplet in red microscope light — The formation of a blood clot is studied in microscope Photographer: Karin Söderlund Leifler

The Haemostasis Research Group at department of Biomedical and Clinical Sciences, division Clinical Chemistry and Pharmacology is led by professor emeritus Tomas L. Lindahl.

At the lab there is one 1st research engineer and part-time four clinicians who are PhD students (with Lindahl as second supervisior).

We study regulation of platelet activation and interaction with coagulation- from biochemistry and genes to clinical studies on antithrombotic drugs in cardiovascular diseases and how covid-19 causes thrombosis. Furthermore, we develop new diagnostic methods.

The group has collaborations with several clinical researchers at the University Hospital in Linköping, Swedish biotechnology companies and university research laboratories in Sweden and Norway.

Group members

Principal investigator

Members

Ahmed Al-Hashimi

Cia Laine

Mikael Lund

PhD student

Ankit Macwan

Principal Research Engineer

Kjersti Tunströmer

Principal Research Engineer

Collaborators at LiU

Joakim Alfredsson

Senior Associate Professor

Niklas Boknäs

Carl-Johan Carlhäll

Professor

Charlotta Dabrosin

Professor

Margareta Holmström

Senior Associate Professor, Head of Division, Head of Unit

Johanna Ungerstedt

Professor

Kajsa Uvdal

Professor, Head of Division

Amanda Welin

Carl Johan Östgren

Professor

Selected publications

Lindahl TL, Kumar AP, Hallström T, Al-Hashimi A, du Rietz A, Arlaman E, Uvdal K, Macwan AS. Dabigatran Attenuates the Binding of Thrombin to Platelets-A Novel Mechanism of Action. Thromb Haemost. 2025 Aug;125(8):747-756.
Arbring K, Lund M, Onelöv L, Lindahl TL. Evaluation of MRX PT DOAC as a new screening method for detecting interferences in thrombophilia analyses. Scand J Clin Lab Invest. 2025 Feb;85(1):34-40.
Alfredsson J, Wegmann B, Holmström M, Östgren CJ, Larsson A, Lindahl TL. Coagulation factor XI relative to established cardiovascular risk factors and atherosclerosis, in a large middle-aged population. Thromb Res. 2024 Sep;241:109069.
Tunströmer K, Faxälv L, Larsson P, Lindahl TL, Boknäs N. Thrombus remodelling by reversible and irreversible P2Y₁₂ inhibitors. Platelets. 2023 Dec;34(1):2157805.
Boknäs N, Laine C, Hillarp A, Macwan AS, Gustafsson KM, Lindahl TL, Holmström M. Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex. Thromb Res. 2022 May;213:97-104.
Hillarp A, Strandberg K, Gustafsson KM, Lindahl TL. Unveiling the complex effects of direct oral anticoagulants on dilute Russell's viper venom time assays. J Thromb Haemost. 2020 Apr 15. doi: 10.1111/jth.14829. Online ahead of print.

Macwan AS, Boknäs N, Ntzouni MP, Ramström S, Gibbins JM, Faxälv L, Lindahl TL. Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica, 2019;104:1482-1492.
Alfredsson J, Swahn E, Gustafsson KM, Janzon M, Jonasson L, Logander E, Nilsson L, Lindahl TL. Individual long-term variation of platelet reactivity in patients with dual antiplatelet therapy after myocardial infarction. Platelets. 2019;30:572-8.
Heenkenda MK, Lindahl TL, Osman A. Frequency of Ala120Thr PAR4 variant varies widely across Sub-Saharan African populations. Blood. 2018;132:2103-6.
Tunströmer K, Faxälv L, Boknäs N, Lindahl TL. Quantification of Platelet Contractile Movements during Thrombus Formation. Thromb Haemost. 2018;118:1600-11.
Boknäs N, Ramström S, Faxälv L, Lindahl TL. Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders. Platelets. 2018 Jul;29(5):512-519.
Sánchez Centellas D, Gudlur S, Vicente-Carrillo A, Ramström S, Lindahl TL. A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets. Thromb Res. 2017;154:84-92.

News

News from LiU

A view into a blood clot

What really happens inside a blood clot as it forms? To investigate this question in detail, researchers developed a method that enables 3-dimensional images of how blood clots form.

Organisation

Division of Clinical Chemistry and Pharmacology (KKF)

The Division of Clinical Chemistry and Pharmacology (KKF) conducts research and education that includes the subject areas of anesthesiology/intensive care, pharmacology and clinical pharmacology, forensic sciences and clinical chemistry.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

Faculty of Medicine and Health Sciences (MEDFAK)

The Faculty of Medicine and Health Sciences conducts research and education within medicine, healthcare and public health.

Haemostasis Research Group in Linköping