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Anders Rosén

Research on mechanisms behind expansion of antibody-producing clones of B-cells in health and disease

We study recently discovered signaling pathways and redox regulation mechanisms in chronic lymphocytic leukemia (CLL). In CLL, we see a dysfunctional expansion of B-cell clones that produce antibodies against very specific microbes as well as structures on damaged/dying/apoptotic cells.

Our research team is also investigating mechanisms of myalgic encephalomyelitis/chronic fatigue syndrome, ME/CFS. The condition causes severe post-exertional malaise (PEM) and often starts after a viral infection, e.g. glandular fever e.g infectious mononucleosis. This condition share several symptoms with post-covid syndrome. Epstein-Barr virus, EBV, as well as human herpes virus 6, HHV6, are two herpesviruses often reactivated in people with ME/CFS, causing severe fatigue, muscle pain, B-cell expansions, autoantibodies, and an increased risk of lymphoma development if the condition persists for a long time. We study possible mechanisms to break the vicious circle.

About me

Collaborations

  • Hematology Clinic, Linköping
  • Bragée Clinic, Stockholm
  • Prof Giannis Spyrou, LiU
  • Docent Charlotte Dahle, LiU
  • Prof Maria Lerm, LiU

Lab members

Dr. Eirini Apostolou
M.Sc. Ulf Hannestad
Prof. em. Anders Rosén

Previous members

Dr. Björn Ingelsson
M.Sc. Muhammad Rizwan
Dr. Petros Moustardas
Dr. Ann-Charlotte Berg
M.Sc. Kate Easingwood

Publications

Latest publications

2024

Eirini Apostolou, Anders Rosén (2024) Epigenetic reprograming in myalgic encephalomyelitis/chronic fatigue syndrome: A narrative of latent viruses Journal of Internal Medicine (Article in journal) Continue to DOI

2023

Ulf Hannestad, Eirini Apostolou, Per Sjogren, Bjorn Bragee, Olli Polo, Bo Christer Bertilson, Anders Rosén (2023) Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa Frontiers in Medicine, Vol. 10, Article 1208181 (Article in journal) Continue to DOI

2022

Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman, Maria Lerm (2022) Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells Clinical Epigenetics, Vol. 14, Article 172 (Article in journal) Continue to DOI
Eirini Apostolou, Muhammad Rizwan, Petros Moustardas, Per Sjögren, Bo Christer Bertilson, Björn Bragée, Olli Polo, Anders Rosén (2022) Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome Frontiers in Immunology, Vol. 13, Article 949787 (Article in journal) Continue to DOI
Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman, Maria Lerm (2022) Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells

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