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Anders Rosén

Professor Emeritus

Research on mechanisms behind expansion of antibody-producing clones of B-cells in health and disease

Copyright Lennart Nilsson, Cellmaterial Anders Rosén Foto: Copyright Lennart Nilsson, cell material Anders Rosén

We study recently discovered signaling pathways and redox regulation mechanisms in chronic lymphocytic leukemia (CLL). In CLL, we see a dysfunctional expansion of B-cell clones that produce antibodies against very specific microbes as well as structures on damaged/dying/apoptotic cells.

Our research team is also investigating mechanisms of myalgic encephalomyelitis/chronic fatigue syndrome, ME/CFS. The condition causes severe post-exertional malaise (PEM) and often starts after a viral infection, e.g. glandular fever e.g infectious mononucleosis. This condition share several symptoms with post-covid syndrome. Epstein-Barr virus, EBV, as well as human herpes virus 6, HHV6, are two herpeseviruses often reactivated in people with ME/CFS, causing severe fatigue, muscle pain, B-cell expansions, autoantibodies, and an increased risk of lymphoma development if the condition persists for a long time. We study possible mechanisms to break the vicious circle.

Colaborations:

  • Hematology Clinic, Linköping
  • Bragée Clinic, Stockholm
  • Prof Giannis Spyrou, Docent Charlotte Dahle, Prof Maria Lerm, LiU

News

COVID-19 reactivates several latent viruses – particularly in ME patients

COVID-19 reactivated viruses that had become latent in cells following previous infections, particularly in people with chronic fatigue syndrome. The results adds to our knowledge of the causes of the disease and prospects of reaching a diagnosis.
Mammography.

24 million SEK for cancer research at Linköping University

Ten researchers from Linköping University have received more than 24 million Swedish kronor from this year’s allocation of funds from the Swedish Cancer Society.

New warning system discovered in the immune defence

Researchers at LiU have discovered a previously unknown warning system that contributes to the body’s immune system. Mitochondria in the white blood cells secrete a web of DNA fibres that raises the alarm.

Publications

2023

Ulf Hannestad, Eirini Apostolou, Per Sjogren, Bjorn Bragee, Olli Polo, Bo Christer Bertilson, Anders Rosén (2023) Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa Frontiers in Medicine, Vol. 10, Article 1208181 Continue to DOI

2022

Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman, Maria Lerm (2022) Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells Clinical Epigenetics, Vol. 14, Article 172 Continue to DOI
Eirini Apostolou, Muhammad Rizwan, Petros Moustardas, Per Sjögren, Bo Christer Bertilson, Björn Bragée, Olli Polo, Anders Rosén (2022) Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome Frontiers in Immunology, Vol. 13, Article 949787 Continue to DOI
Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson, Eirini Apostolou, Anders Rosén, Kristofer Hedman, Maria Lerm (2022) Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
Johanna Huoman, Shumaila Sayyab, Eirini Apostolou, Lovisa Karlsson, Lucas Porcile, Muhammad Rizwan, Sumit Sharma, Jyotirmoy Das, Anders Rosén, Maria Lerm (2022) Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitro Epigenetics, Vol. 17, p. 1875-1891 Continue to DOI

Publications in ORCHID

Please see my publications in ORCHID

 

Research

Studies on chronic lymphocytic leukemia

We reported a novel finding on the highly resticted and biased specificities of CLL Abs some years ago, showing limited target structures for the CLL Abs, which were exposed on oxidized-LDL, apoptotic cells...

Research group

Principal investigator

Photo of Anders Rosén

Anders Rosén

Professor Emeritus
 

Eirini Apostolou

Principal Research Engineer
 
Photo of Ulf Hannestad

Ulf Hannestad

Previous members

Dr. Björn Ingelsson
M.Sc. Muhammad Rizwan
Dr. Petros Moustardas
Dr. Ann-Charlotte Berg

Related Research

Cell and Molecular Biology

Molecular Biology research focus on  how molecules and systems within cells interact. Of special interest is the flow of genetic information from DNA via RNA to protein synthesis, and how these processes are regulated.
Cancerceller, illustration

Cancer and Hematology

Cancer is a unifying concept for a number of diseases where abnormal cells divide , sometimes uncontrolled and invading other tissues.
Image of molecules that will take you to WCMM's homepage.

Wallenberg Centre for Molecular Medicine at LiU

WCMM at LiU focuses on the medicine-technology interface, and build upon our existing strengths in research within medical technology, materials science and bioengineering.

Organisation

Teaser image for the division CELLB at BKV.

Division of Cell Biology (CELLB)

The main research focus of the Division of Cell Biology is to understand the construction and function of cells.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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