We study recently discovered signaling pathways and redox regulation mechanisms in chronic lymphocytic leukemia (CLL). In CLL, we see a dysfunctional expansion of B-cell clones that produce antibodies against very specific microbes as well as structures on damaged/dying/apoptotic cells.
Our research team is also investigating mechanisms of myalgic encephalomyelitis/chronic fatigue syndrome, ME/CFS. The condition causes severe post-exertional malaise (PEM) and often starts after a viral infection, e.g. glandular fever e.g infectious mononucleosis. This condition share several symptoms with post-covid syndrome. Epstein-Barr virus, EBV, as well as human herpes virus 6, HHV6, are two herpeseviruses often reactivated in people with ME/CFS, causing severe fatigue, muscle pain, B-cell expansions, autoantibodies, and an increased risk of lymphoma development if the condition persists for a long time. We study possible mechanisms to break the vicious circle.
- Hematology Clinic, Linköping
- Bragée Clinic, Stockholm
- Prof Giannis Spyrou, Docent Charlotte Dahle, Prof Maria Lerm, LiU