During my PhD, I investigated why adipocytes from type 2 diabetic patients are insulin-resistant. My interest was sparked by reports from the Dutch Hunger Winter, which suggested that parental starvation increases the risk of their children developing obesity and type 2 diabetes as adults. Currently, my research projects focus on studying diet-driven sperm modifications across species, understanding the role of small RNA in male fertility, and exploring how small RNA in sperm might influence embryo development.
Anita Öst
Professor, Head of Division
Many factors contribute to proper embryogenesis. By studying the variations in these early life events, I hope to uncover insights that will lead to new treatments for obesity and metabolic disorders such as type 2 diabetes.
Exploring Diet, RNA, and Developmental Impact of Sperm
Selected publications
Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm
Tidskrift: Antioxidants and Redox Signaling (2023)
Författare: Rashmi Ramesh, Signe Skog, Lovisa Örkenby, Unn Örtegren Kugelberg, Daniel Nätt, Anita Öst
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Human sperm displays rapid responses to diet
Tidskrift: PLoS biologyFörfattare: Daniel Nätt, Unn Örtegren Kugelberg, Elizabeth Nedstrand, Stefan Zalavary, Pontus Henriksson, Carola Nijm, Julia Jaderquist, Johanna Sandborg, Eva Carlsson Flinke, Rashmi Ramesh, Lovisa Örkenby, Filip Appelkvist, Thomas Lingg, Marie Löf, Anita Öst
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Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Tidskrift: CELL (2014)
Författare: Anita Öst, Adelheid Lempradl, Eduard Casas, Melanie Weigert, Theodor Tiko, Merdin Deniz, Lorena Pantano, Ulrike Boenisch, Pavel M Itskov mfl.
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News
Research
Video about the research
Fruit flies helping to solve the riddle of obesity
Our weight is governed by our lifestyle and our genes. But new research at Linköping University has shown that the lifestyle of parents – before children are conceived – appears to impact their offspring’s weight. Anita Öst, professor at Linköping University, is also a Wallenberg Academy Fellow.
Education
Metabolism - a plainsplain Youtube channel
These video clips are produced for teaching at the Medical programme at the Faculty of medicine and health sciences at Linköping university.