Identification of pain modulating substances and their associated molecular mechanisms is necessary to understand the pathophysiology behind chronic pain. Our research contributes to the development of mechanism-based pain diagnoses and in the long term contributes to the development of more effective treatment methods.
The PAINOMICS research group has a strong track record in the field of musculoskeletal and neuropathic pain research. The research group consists of clinical and preclinical researchers that together investigate following areas:
- Identification of single or a panel of multiple biomarkers that reflect the molecular signature of chronic pain
- Identifying molecular biomarker profiles (patterns of proteins, lipids, algesics and inflammation substances) for different chronic pain conditions, e.g., neuropathic pain, chronic back pain, chronic widespread pain/fibromyalgia
- Analyze if the balance between pain excitatory and inhibitory substances differs between different chronic pain conditions
- Investigate the correlations between levels of spinal and peripheral pain excitatory/inhibitory substances and clinical characteristics of pain e.g., duration, intensity, anatomical spreading in the body and signs of sensitization/hyperexcitability
