May 2025
π Conference: Antonios and Suheda travelled to Alpbach, Austria for the 2025 European Calcium Channel Conference! Antonios gave a talk titled “A rich conformational palette underlies human CaV2.1-channel availability”.
π° Publication: Angelini M, Savalli N, Steccanella F, Maxfield S, Pozzi S, DiFranco M, Cannon SC, Pantazis A, Olcese R. The molecular transition that confers voltage dependence to muscle contraction. Nat Commun. 2025 May 24;16(1)4847. doi: 10.1038/s41467-025-59649-7. Link to article
π Conference: Antonios, Amaya, Serena and Suheda went to gorgeous Kolmården to attend the Center for Systems Neuroscience “Neuroretreat”! Antonios co-organized the “Ion Channels of the Nervous System” symposium, and talked about “The secret lives of presynaptic calcium channels”. Other guests were Angelika Lampert, Stephanie Schorge and Philippe Lory.
April 2025
π° Publication: Dahlberg P[1], Pozzi S[1], Bulmer L, Golluscio A, Nilsson M, Nygren A, Larsson HP, Pantazis A[2], Gummesson A[2]. Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia. J Mol Cell Cardiol. 2025 Apr 8:S0022-2828(25)00059-8. doi: 10.1016/j.yjmcc.2025.04.001.
[1], [2] = equal contribution
Link: https://www.jmcc-online.com/article/S0022-2828(25)00059-8/fulltext
Blue-torial: https://bsky.app/profile/antoniospantazis.bsky.social/post/3lmovebfvak2d
π Conference: Antonios talked about “Even a single carbon atom matters: deadly and unexpected consequences of a NaV1.5 variant” at the Worldwide Sodium Channel Seminar series.
π Conference: Antonios talked about “The molecular mystery in a case of familial cardiac arrhythmia” at the LiU Medical Faculty “Academic Quarter” seminar series.
π° Publication: Wang K, Nilsson M, Angelini M, Olcese R, Elinder F, Pantazis A. A rich conformational palette underlies human CaV2.1-channel availability. Nat Commun. 2025 Apr 23;16(1):3815. doi: 10.1038/s41467-025-58884-2. Links to article & press release
February 2025
π π Conference & Award: We went to the Biophysical Society meeting, in Los Angeles, CA! Serena and Süheda presented posters, and Süheda also gave a talk. Amaya presented a poster on her work at the Elinder group. Congratulations to Serena for receiving a travel award!
π° Pre-print: Nappi M, Frampton DJA, Kusay AS, Wang K, Miceli F, Liin SI, Taglialatela M, Pantazis A: Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation. bioRxiv [Preprint] 2025. doi: https://doi.org/10.1101/2025.02.04.636443
January 2025
π£News: Antonios was interviewed by the Östgöta taltidning audio newspaper about our latest research on CaV2.2 inhibition, its exploitation by opioid drugs, and its promise for the development of novel analgesics! Link to audio article (in English & Swedish).