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Henrik Green

Deputy Head of Department, Professor

My research aims to better understand the mechanism of action and toxicity of new psychoactive substances, drugs of abuse and cancer chemotherapy including prediction models. I also work on how to solve murders using post-mortem metabolomics and AI.

Presentation

Genetics and Toxicology in Cancer Chemotherapy and Forensic Sciences

My research is focused on finding predictive markers and understanding how pharmaceuticals and drugs yield desired and undesired effects in humans.

Everyone is different and everyone reacts differently to drugs. Our research group studies how genetic variation affects the effect and risk of side effects in cancer treatment. We also work with new psychoactive drugs (internet drugs), their toxicology and pharmacology. Our third track is genetics in a forensic perspective.

Publications

2024

Tobias Rautio, Matthew J. Connolly, Huiling Liu, Peter Konradsson, Henrik Green, Johan Dahlén, Xiongyu Wu (2024) Direct and selective alkylation of indazole-3-carboxylic acid for the preparation of synthetic cannabinoids and metabolites FORENSIC CHEMISTRY, Vol. 40, Article 100603 (Article in journal) Continue to DOI
Manuela Monti, Liam M. De Vrieze, Marthe M. Vandeputte, Mattias Persson, Henrik Green, Christophe P. Stove, Gotz Schlotterbeck (2024) Detection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole "nitazene" class Journal of Pharmaceutical and Biomedical Analysis, Vol. 251, Article 116453 (Article in journal) Continue to DOI
Liam Ward, Sara Kling, Gustav Engvall, Carl Soderberg, Fredrik Kugelberg, Henrik Green, Albert Elmsjo (2024) Postmortem metabolomics as a high-throughput cause-of-death screening tool for human death investigations iScience, Vol. 27, Article 109794 (Article in journal) Continue to DOI
Albert Elmsjo, Liam J. Ward, Kie Horioka, Shimpei Watanabe, Fredrik Kugelberg, Henrik Druid, Henrik Green (2024) Biomarker patterns and mechanistic insights into hypothermia from a postmortem metabolomics investigation Scientific Reports, Vol. 14, Article 18972 (Article in journal) Continue to DOI
Mattias Persson, Robert Kronstrand, Michael Evans-Brown, Henrik Green (2024) In vitro activation of the CB<sub>1</sub> receptor by the semi-synthetic cannabinoids hexahydrocannabinol (HHC), hexahydrocannabinol acetate (HHC-O) and hexahydrocannabiphorol (HHC-P) Drug Testing and Analysis (Article in journal) Continue to DOI

News

Henrik Green.

Nerve damage from cancer treatment can be predicted

Many women treated for breast cancer using taxanes, a type of cytostatic drug, often experience side effects in the nervous system. Researchers at LiU have developed a tool that can predict the risk level for each individual.
Three men and a woman outside Campus US.

SciLifeLab establishes a new research site at LiU

Technology, expertise, methods and initiatives can be coordinated more within and between higher education institutions. Linköping University is now one of four new sites in the Swedish research infrastructure SciLifeLab.
Male researcher in lab, blue background light.

SEK 13 million for research into solving murders using AI

Was it murder, poisoning or was the death maybe caused by disease? Researchers have now been granted SEK 13 million from the Swedish Research Council to develop a methodology to solve crimes using detailed analyses and artificial intelligence.

Networks and collaborations

Sequencing DNA.

Strategic Research Area in Forensic Sciences

The Strategic Research Area in Forensic Sciences is a joint venture between the National Board of Forensic Medicine in Sweden and Linköping University.
Illustrative image of cancer cells and networks.

Cancer

Cancer is a research network for scientists and health care professionals at Linköping University and at the County Council of Östergötland (Region Östergötland). The research is related to cancer diagnosis, pathogenesis and treatment.

Research videos

The hunt for the new drug, screenshot.

The hunt for the new drug - Sverige forskar

The drug trade is usually one step ahead of the legislators because each preparation must be classified as a drug separately before they are banned. But now the researchers at Linköping University can make the hunt for the drugs go much faster.

introduction picture with headshot and title of presentation.

Internet drugs – occurrence, pharmacology and classification as narcotic drugs

How dangerous are internet drugs really and how do they spread in society? Henrik Gréen, professor of forensic sciences, talks about the never-ending influx of new drugs, and about how his and others‘ research makes a difference in getting drugs classed as narcotic drugs and protecting lives.

About me

CV

Currently:

  • Professor in forensic sciences at Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medical Sciences, Linköping University.
  • Researcher / Molecular Biologist in Engineering and Genomics. Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping.

Previously:

  • 2012 - 2020: Research strategist / Molecular Biologist in Engineering and Genomics. Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping and associated with Linköping University
  • 2011 - 2012: Post-doc at Science for Life Laboratory, Division of Gene technology, Institution for Biotechnology, KTH - Royal Institute of Technology.
  • 2007 - 2012: Assistant Professor at the Division of Drug Research, Linköping University, Linköping Sweden.

Education

  • 2000 - Master of Science in Engineering Biology. Institute of Technology, Linköping University, Linköping, Sweden.    
  • 2007 - PhD in Clinical Pharmacology. Division of Clinical Pharmacology, Department of medicine and Care, Faculty of Health Sciences, Linköping University, Linköping, Sweden. 
  • 2012 - Associate Professor in Pharmacogenetics at Linköping University.

Co-workers

Robert Kronstrand

Adjunct Professor

Photo of Martin Josefsson

Martin Josefsson

Adjunct Associate Professor, Docent

Photo of Peter Konradsson

Peter Konradsson
Photo of Johan Dahlén

Johan Dahlén

Associate Professor, Docent

Elisabeth Åvall Lundqvist

Organisation

Division of Clinical Chemistry and Pharmacology (KKF)

The Division of Clinical Chemistry and Pharmacology (KKF) conducts research and education that includes the subject areas of anesthesiology/intensive care, pharmacology and clinical pharmacology, forensic sciences and clinical chemistry.

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.
Five people in a laboratory.

Faculty of Medicine and Health Sciences (MEDFAK)

The Faculty of Medicine and Health Sciences conducts research and education within medicine, healthcare and public health.

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