Non-invasive diagnosis of fatty liver disease and sarcopenia

I received my medical degree from Linköping University in 2013 and I'm doing a residency in internal medicine and in gastroenterology and hepatology at Linköping University Hospital. I defended my thesis "Non-Alcoholic Fatty Liver Disease: Aspects on Diagnosis and Long-term Prognosis" in 2019 and I'm currently involved in several prospective studies focusing on chronic liver diseases (mainly NAFLD) and cirrhosis as part of The Study Group of Ectopic Fat Storage. Furthermore, I’m doing a postdoc at the Karolinska Institute, as part of the Hagström group.

Chronic liver diseases are highly prevalent globally. Non-alcoholic fatty liver disease, or NAFLD, is the most common chronic liver disease, affecting approximately 25% of the adult population worldwide. NAFLD is often seen as the hepatic manifestation of the metabolic syndrome, which includes overweight/obesity, type 2 diabetes mellitus, dyslipidemia, and hypertension. The prevalence of NAFLD is expected to rise in parallel with the ongoing epidemic of obesity and type 2 diabetes mellitus.

NAFLD entails an increased risk of liver-related events associated with cirrhosis, such as ascites, esophageal varices, hepatic encephalopathy, and hepatocellular carcinoma (HCC). Even though NAFLD progresses slowly (over decades), and only circa 5% develop cirrhosis, it is now the leading cause of HCC and the second leading etiology for liver transplantation.

The gold standard for diagnosing and staging chronic liver diseases is by histopathological evaluation, which requires a liver biopsy. However, recently, novel biomarkers such as magnetic resonance (MR) imaging, has shown promise in replacing liver biopsy for quantification and evaluation of hepatic fat accumulation and fibrosis, portal blood flow, body composition and sarcopenia.

Currently, the most validated non-invasive biomarkers are easily available blood-based scores, advanced MR exams and vibration controlled transient elastography (e.g., Fibroscan®). However, several new biomarkers are under investigation, with experimental blood- and gene-based analyses, radiological techniques, and cytokines being thoroughly evaluated. Moreover, body composition, sarcopenia, and structural heart changes have shown an intricate relationship associated with cardiovascular and liver-related outcome in individuals with chronic liver diseases.

The relationship between body composition, sarcopenia and chronic liver diseases is poorly understood. However, sarcopenia seems to be associated with a more dismal prognosis in patients with chronic liver diseases, and especially liver cirrhosis.

The main purpose of our projects is to untangle the relationship between chronic liver disease, body composition and sarcopenia, and its relevance for diagnosis, prognosis, and treatment. Furthermore, we aim to define clinically relevant risk phenotypes amongst individuals with chronic liver diseases, and especially non-alcoholic fatty liver disease.

About me


  • 2007-2013 Medical Degree, Linköping University, Sweden
  • 2013-2015 Internship, Linköping University Hospital (US), Sweden
  • 2015- Resident, Internal medicine, US, Sweden
  • 2015- Resident, Gastroenterology and Hepatology, US, Sweden
  • 2020- Posdoc, Karolinska Institutet, Stockholm, Sweden
  • 2020- Member of the Linköping Medical Association

Teaching assignments

  • 2013- Teaching assignments at the Medical Programme Linköping
  • 2021- Co-supervisor for PhD-students
  • 2015- Examiner at the Medical Programme in Linköping





Research projects:

  • NFL
  • FLIS-2
  • UK Biobank


  • Mattias Ekstedt
  • Wile Balkhed
  • Julia Blomdahl
  • Byron Lykiardopoulo
  • Stergios Kechagias
  • Mikael Forsgren
  • Olof Dahlqivst Leinhardt
  • Jennifer Linge
  • Gunnar Cedersund
  • Valentin Kindesjö
  • Nils Dahlström
  • Bengt Norén
  • Wolf Bartholomä
  • Peter Lundberg
  • Johan Kihlberg
  • Carl Johan Carlhäll
  • Tino Ebbers
  • Carl Edin
  • Joakim Alfredsson
  • Torsten Olbers
  • Bijar Ghafour
  • Cecilia Jönsson
  • Christian Simonsson
  • Martin Henriksson
  • Lina Gruneau
  • Fredrik Iredahl
  • Martin Ulander
  • Martin Bergram
  • Karin Rådholm
  • Simone Ignatova