Beyond lipids and inflammatory markers, a new type of blood test for cardiovascular risk estimation has emerged in recent years, namely the measurement of extracellular matrix proteins. In our research, we quantify these blood borne proteins amongst other circulating biomarkers and explore how the levels are associated with coronary artery disease and ascending aortic dilatation. The goal is to increase the understanding of these proteins in relation to cardiovascular risk and we hope that this could facilitate clinical use in the future. The research is performed within general population-based cohorts based in Sweden such as the LSH and SCAPIS cohort.
Filip Hammaréus
I combine my profession as a Resident Physician in Cardiology with research on circulating biomarkers in blood and how these affect the risk for coronary artery disease and ascending aortic dilatation.
The measurement of extracellular matrix biomarkers in blood – a new way to determine cardiovascular risk?
Cardiovascular disease remains the number one cause of morbidity and mortality worldwide.
In spite of enormous scientific breakthrougs in terms of determining cardiovascular risk, the challenge remains on how to fully determine cardiovascular risk for the specific patient. With an aging population and newer, better but also more expensive treatment options, cardiovascular risk estimation is belived to play an even larger role in the future.
Beyond lipids and inflammatory markers, a new type of blood test for cardiovascular risk estimation has emerged in recent years, namely the measurement of extracellular matrix proteins. In our research, we quantify these blood borne proteins amongst other circulating biomarkers and explore how the levels are associated with coronary artery disease and ascending aortic dilatation. The goal is to increase the understanding of these proteins in relation to cardiovascular risk and we hope that this could facilitate clinical use in the future. The research is performed within general population-based cohorts based in Sweden such as the LSH and SCAPIS cohort.
Beyond lipids and inflammatory markers, a new type of blood test for cardiovascular risk estimation has emerged in recent years, namely the measurement of extracellular matrix proteins. In our research, we quantify these blood borne proteins amongst other circulating biomarkers and explore how the levels are associated with coronary artery disease and ascending aortic dilatation. The goal is to increase the understanding of these proteins in relation to cardiovascular risk and we hope that this could facilitate clinical use in the future. The research is performed within general population-based cohorts based in Sweden such as the LSH and SCAPIS cohort.
About me
CV
- Accepted into medical school LiU autumn 2017
- Accepted into ”forskarlinjen” spring 2021
- PhD student since August 2021
- Degree of Master of Science in Medicine (M.D. equivalent), January 2023
- Intern Physician region Jönköpings län since February 2023
- License to practice medicine May 2025
- Junior physician in the departement of Cardiology, Linköping University Hospital, Linköping, May 2025 – May 2026
- Resident Physician in Cardiology, departement of Cardiology, Linköping University Hospital, Linköping, June 2026-
- PhD degree in medicine September 2026
Network
- LiU CircM
- Forskarlinjen
Publications
2026
Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study
BMC Cardiovascular Disorders, Vol. 26, Article 821
(Article in journal)
https://dx.doi.org/10.1186/s12872-026-06616-9
Exploring Circulating Extracellular Matrix related Biomarkers in Coronary Artery Disease and Ascending Aortic Dilation: Findings from Swedish Population-based Cohorts
(Doctoral thesis, comprehensive summary)
https://dx.doi.org/10.3384/9789181185577
Circulating type I collagen pro-a1 chain is inversely associated with the presence of coronary atherosclerosis in a Swedish middle-aged population
Scientific Reports, Vol. 16, Article 9965
(Article in journal)
https://dx.doi.org/10.1038/s41598-026-45736-2
2025
Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population
Heart, Vol. 111, p. 904-909
(Article in journal)
https://dx.doi.org/10.1136/heartjnl-2024-325409
2024
Abnormal Patterns of Wall Shear Stress in Aortic Dilation Revealed by Permutation Tests
Journal of Cardiovascular Magnetic Resonance, Vol. 26, Article 100612
(Article in journal)
https://dx.doi.org/10.1016/j.jocmr.2024.100612
Research projects
- Dilatation of the Ascending Aorta in SCAPIS (The AscA study)
- Life conditions, stress and health study (The LSH study)
- A study on immunity, diet and atherosclerosis in SCAPIS (SCAPIS Leukocyte)
- SweSCAD (a national research network on spontaneous coronary artery dissection)