Autoimmunity and allergy

The adaptive immune system with its T-cells and antibody-producing B-cells changes throughout your entire life. In addition, we have a range of innate or native defence factors ready to quickly repel threats from the environment.

Astma och allergi Foto: istockPhoto credit: Rob Hainer
In autoimmune diseases, the immune system tries to neutralize or eliminate the body's own cells or tissues. Symptoms then arise as a consequence of inflammation and/or a decline in cell or organ function. Examples of autoimmune diseases are certain rheumatic conditions such as rheumatoid arthritis and SLE (systemic lupus erythematosus), hormonal diseases such as diabetes and goiter, and neurological diseases such as MS (multiple sclerosis).
 
Allergies in everyday speech most often mean “Type I allergies” (atopic allergies) where IgE antibodies are aimed at certain foodstuffs, pollen, cat dander, et cetera. When a person with such an allergy is exposed to these substances (allergens), symptoms arise, for example in the form of runny eyes/nose (‘hayfever’), rash (urticaria) or asthma. Autoimmune diseases and allergies are, as a rule, chronic conditions, which can cause significant impairment of function and can sometimes be life-threatening. Even if these conditions can now often be partially treated due to advances in immunology and inflammation medicine, much research remains before we can gain full understanding of the underlying mechanisms and obtain cures.

News

young woman in a wheelchair.

Severe MS predicted using machine learning

A combination of only 11 proteins can predict long-term disability outcomes in multiple sclerosis (MS) for different individuals. The proteins could be used to tailor treatments to the individual based on the expected severity of the disease.

Older man engaged in a discussion.

Gut flora disrupted many years before onset of child rheumatism

A study by researchers from LiU and the University of Florida is the first study to point to the role of early life gut flora in developing child rheumatism, the cause of which is not yet known.

Yawning baby.

Researching gut bacteria as protection against disease

Did the bacteria in your guts when you were a baby impact your risk of future disease? We have talked to researcher studying whether diseases such as type 1 diabetes and allergy could be prevented by promoting the right bacteria early in life.

Research

The Nestor Lab

Our research aims to understand the function of DNA methylation in the biology of human CD4+ T-cells, and use this knowledge to dissect its role in disease.

Experimental and Clinical Studies of Psoriasis

We are studying the pathogenesis of the disease in experimental systems using broad cell biological techniques. Special interest is devoted to psoriasin which is a small protein...

Ingrid Asp Psoriasis Research Center

Our research program has been made possible by a generous donation from the Ingrid Asp Foundation. Our ultimate goal is to obtain an improved understanding of the pathogenesis of psoriasis and to find new modalities for its therapy.

Research center