The Nestor Lab (Epigenetic Control of Human T-cell Biology)

Lab work

Human development results in the establishment and maintenance of hundreds of functionally distinct cell types from a single invariant DNA sequence, our genome.

How different cell states are established, maintained and passed on during cell division is controlled by gene regulatory networks and epigenetics which serve to reinforce a cell’s molecular identity. DNA methylation is an epigenetic system essential for human life that is often disrupted in disease.

My research aims to understand the function of DNA methylation in the biology of human CD4+ T-cells, and use this knowledge to dissect its role in disease. Understanding the function of DNA methylation in normal human biology, will allow us to understand its role in disease, with the ultimate goal of developing new drugs that target DNA methylation.

Flaw discovered in epigenetics research method

An error in one of the most widely used methods in epigenetics, DIP-seq, can cause misleading results, researchers at Linköping University, Sweden, have shown. This may have major significance in the research field, where “big data” and advanced methods of DNA analysis are used to study vast amounts of epigenetic data.

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2021

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Logotype Swedish Child Cancer Foundation

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