Infection and Inflammation

Inflammation is a complex host reaction to foreign substances or cell and tissue injury. It can be caused by foreign microorganisms or by the immune system attacking its own tissue.

Virus. Foto: Istock

Inflammation is initiated in the peripheral blood vessels that become permeable to plasma proteins and immune cells, which leave the blood stream, and recruited to, and decontaminate microorganisms and dead cells in the tissue. Inflammation has a protective function but it can also induce tissue damage and disease. This can lead to damage to the host tissue. Normally, this damage is repaired when the inflammation wears off. If the infection is not eliminated or the tissue damage remains, the inflammation can become chronic.

Many infections are caused by viruses, which can be harder to treat than bacteria. The development of vaccines and antibiotics has reduced many serious infectious diseases. Overuse of antibiotics has, however, led to widespread resistance to many antibiotics, e.g. staphylococcus (MRSA) and Gram-negative bacteria but also against other microorganisms such as tuberculosis bacteria.

Research in the field of inflammation at LiU stretches over a broad area. Important areas are the origin and treatment of allergies and autoimmune diseases, vaccines and human genetic factors in virus infections, inflammation in mucus membranes, tuberculosis, resistance to antibiotics, tick-borne infections, and the role of inflammation in cardiovascular disease.

Clinical microbiology

Microbiology is the science of microorganisms, chiefly bacteria and fungi. Within clinical microbiology, they are studied from the viewpoint of health care and medical treatment. At LiU the interplay between host and microorganism is studied, for example chlamydia, borrelia, mycobacteria, lactobacilli, staphylococcus and enterococcus. 

Medical microbiology

Medical microbiology comprises studies of microorganisms that have the ability to cause illness in humans. One of the pioneers in the field was Louis Pasteur (1822-1895), the man behind the rabies vaccine and the pasteurization of milk and wine. Research at LiU is directed towards allergies, infection, inflammation, and autoimmune diseases, as well as the origin of biofilm on tissues, and medical tools.


A virus can only reproduce itself within a living host cell. Viruses spread in many ways: through insects, as droplets in coughing and sneezing, through bodily waste products or sexual contact. Research at LiU focuses on such things as the physiological mechanisms of viral diseases, immunity, vaccines, and genetic factors in humans that affect susceptibility to viral infections.

Doctor wearing highly protective suit and holding globe in her hands

Regional Infectious Disease Epidemiology and Simulations - RIDES

Our research concerns epidemiological data and information processing in connection with infectious disease outbreaks at local and regional level.

An adult's hand holds the hand of a premature baby.

N-forte trial

The aim of the N-forte trial is to explore how breast milk composition influences the development of NEC, sepsis and neurological impairment in extremely preterm infants in order to improve future treatments in this patient group.

It’s in your DNA - your body’s experiences become imprinted as methylation signatures!

Our research explores how infections like COVID-19 and tuberculosis alter DNA through epigenetic changes. Tuberculosis exposure leaves marks in immune and other cells. COVID-19 also rewires immune cell DNA, offering diagnostic insights.


Cell culture flask under a microscope in a lab.

They grow nose tissue in the lab

LiU researchers are among the first in the world to have grown human nasal tissue from stem cells. It is used to study how different viruses infect the airways.

Four people working with a gull.

Gulls spread dangerous bacteria around the world

Gulls can sometimes be a nuisance for people who want to enjoy a picnic or an ice cream. They can also be carriers of genes that make bacteria resistant to antibiotics. This is shown by the research led by Jonas Bonnedahl.

man working with bacteria culture in laboratory.

Pioneering safe chemotherapy methods for treating infections

Antibiotic resistant bacteria are a threat to human lives, and yet the development of new drugs is slow. A group of proven cancer drugs could possibly be the solution. A new class of antibiotics is now being developed by researchers at LiU.