Home

DETECT-HCC-ESLD

A X-ray image of a liver
Photographer: SEBASTIAN KAULITZKI/SCIENCE PHOT

A comparative study of MRI and ultrasound for detection of primary hepatocellular carcinoma, body composition and risk factors for decompensation in liver cirrhosis (DETECT-HCC-ESLD)

In liver cirrhosis, sometimes referred to as hepatic fibrosis, there is an increased risk of several serious complications such as abdominal fluid accumulation (ascites), liver cancer, and muscle mass loss. As patients with liver cirrhosis are at risk of developing these complications, they are closely monitored using various methods including ultrasound, gastroscopy, and regular visits to liver clinics. This study evaluates how effectively these complications (ascites, liver cancer, and muscle mass loss) can be detected and monitored, comparing ultrasound with a shortened MRI scan, conducted every six months as part of liver cancer surveillance. Additionally, blood samples are analysed to identify proteins, genetic predispositions, or gene expressions that may be linked to the future risk of developing liver disease complications or detecting them at an early stage.
This clinical trial is conducted at more than ten hospitals in collaboration with Linköping University, which is the main sponsor and coordinator. The study will include 600 patients from various regions in Sweden, Iceland, and Finland.
The aim is to improve care for patients with liver cirrhosis, enabling more patients to be cured of liver cancer and reducing the number who develop severe complications related to cirrhosis. The study will also provide new tools for the pharmaceutical industry to better design future drug trials.

En bild på Detect forskargrupp


Study Design

Matrix
Data examinations

ContaCt

Head of research

Photo of Mattias Ekstedt

Mattias Ekstedt

Deputy Head of Department, Senior Associate Professor

Project manager

Photo of Kajsa Gomez Svensson

Kajsa Gomez Svensson

Senior Coordinator
Photo of Peter Lundberg

Peter Lundberg

Adjunct Professor

Photo of Nils Dahlström

Nils Dahlström

Associate Professor, Head of Unit

Photo of Patrik Nasr

Patrik Nasr

Adjunct Associate Professor, Docent

Placeholder for missing image of Stergios Kechagias

Stergios Kechagias

Professor

Photo of Tomas Bjerner

Tomas Bjerner

Professor

Photo of Wile Balkhed

Wile Balkhed
Photo of Mikael Forsgren

Mikael Forsgren

Adjunct Associate Professor

Photo of Olof Dahlqvist Leinhard

Olof Dahlqvist Leinhard

Associate Professor

Photo of Cecilia Jönsson

Cecilia Jönsson

Principal Research Engineer

Photo of Markus Holmberg

Markus Holmberg
Photo of Karin Hedin

Karin Hedin

PhD student

Wolf Bartholomä

PhD student

Daniel Sjögren

PhD student

Signe Swerkersson

Doktorand

Organisation

Two scientists are sitting infront of an MRI

Center for Medical Image Science and Visualization, CMIV

CMIV är ett tvärvetenskapligt forskningscentrum vid LiU, etablerat i samarbete med Region Östergötland och Sectra. Vårt uppdrag är att forma framtidens hälso- och sjukvård genom banbrytande forskning inom medicinsk bildanalys och visualisering.
Illustration of the letters HMV

Department of Health, Medicine and Caring Sciences (HMV)

The research areas at HMV include experimental basic research to clinical, social and public health research. We conduct high-quality education in the sought-after care professions.
Five people in a laboratory.

Faculty of Medicine and Health Sciences (MEDFAK)

The Faculty of Medicine and Health Sciences conducts research and education within medicine, healthcare and public health.

Tags