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DETECT-HCC-ESLD

A X-ray image of a liver Photographer: SEBASTIAN KAULITZKI/SCIENCE PHOT

A comparative study of MRI and ultrasound for detection of primary hepatocellular carcinoma, body composition and risk factors for decompensation in liver cirrhosis (DETECT-HCC-ESLD)

In liver cirrhosis, sometimes referred to as hepatic fibrosis, there is an increased risk of several serious complications such as abdominal fluid accumulation (ascites), liver cancer, and muscle mass loss. As patients with liver cirrhosis are at risk of developing these complications, they are closely monitored using various methods including ultrasound, gastroscopy, and regular visits to liver clinics. This study evaluates how effectively these complications (ascites, liver cancer, and muscle mass loss) can be detected and monitored, comparing ultrasound with a shortened MRI scan, conducted every six months as part of liver cancer surveillance. Additionally, blood samples are analysed to identify proteins, genetic predispositions, or gene expressions that may be linked to the future risk of developing liver disease complications or detecting them at an early stage.
This clinical trial is conducted at more than ten hospitals in collaboration with Linköping University, which is the main sponsor and coordinator. The study will include 600 patients from various regions in Sweden, Iceland, and Finland.
The aim is to improve care for patients with liver cirrhosis, enabling more patients to be cured of liver cancer and reducing the number who develop severe complications related to cirrhosis. The study will also provide new tools for the pharmaceutical industry to better design future drug trials.

En bild på Detect forskargrupp


Collaborations

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Study Design

Matrix
Data examinations

Contact

Head of research

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Mattias Ekstedt

Deputy Head of Department, Senior Associate Professor

Project manager

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Kajsa Gomez Svensson

Senior Coordinator
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Peter Lundberg

Adjunct Professor

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Nils Dahlström

Associate Professor, Head of Unit

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Patrik Nasr

Adjunct Associate Professor, Docent

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Stergios Kechagias

Professor

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Tomas Bjerner

Professor

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Wile Balkhed
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Mikael Forsgren

Adjunct Associate Professor

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Olof Dahlqvist Leinhard

Associate Professor

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Cecilia Jönsson

Principal Research Engineer

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Markus Holmberg
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Karin Hedin

PhD student

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Wolf Bartholomä

PhD student

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Daniel Sjögren

PhD student

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Signe Swerkersson

Doktorand

Organisation

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Center for Medical Image Science and Visualization, CMIV

CMIV conducts focused front-line research providing solutions to tomorrow’s clinical issues. The CMIV mission is to develop future methods and tools for image analysis and visualization for applications within health care and medical research.
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Department of Health, Medicine and Caring Sciences (HMV)

The research areas at HMV include experimental basic research to clinical, social and public health research. We conduct high-quality education in the sought-after care professions.
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Faculty of Medicine and Health Sciences (MEDFAK)

The Faculty of Medicine and Health Sciences conducts research and education within medicine, healthcare and public health.
Five man are standing in front of a big screen showing MR images.

The study group of ectopic fat storage

Vi studerar hur fettinlagring i olika organ, så som lever, muskel och hjärta, ökar risken för sjukdomsutveckling. Förhoppningen är att kartläggning kommer att hjälpa oss att identifiera de individer som löper högst risk att utveckla sjukdom.

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