Home
Researcher examines a nerve cell
Biointeractive technologies
Interdisciplinary research fields

Profile area - Life Science Technologies - LSX

The Life Science Technologies profile area includes interdisciplinary research in medicine, natural and engineering sciences, an area where basic research can be developed and contribute to new and important clinical applications.

Interdisciplinary collaboration

Modern medicine and biomedical research are highly dependent on advanced life science technologies (LSX), designed to interface, augment, and provide a deeper understanding of complex biological systems. We live in an era of convergence when new and unexpected discoveries are generating radically new directions in biology, medicine, and technology for preventing, diagnosing, and treating diseases. At LiU, we are at the forefront of this development. With a firm foundation in engineering and science, we address problems that range from fundamental biomedical research to clinical medicine, with the ambition to create new knowledge and develop breakthrough technologies for the benefit of human health and well-being.

The overall aim of the LSX profile area is to further strengthen the interdisciplinary environment between the Faculty of Science and Engineering and the Faculty of Medicine and Health Sciences at LiU, ensuring that we will continue to pioneer and develop the technologies needed to address current and future global healthcare challenges.

Research Projects

The main research activities are focused on development of bio- and tissue interactive technologies for improved health and are centered around seven well-defined research areas that engage researchers from both the Faculty of Science and Engineering and the Faculty of Medicine and Health Sciences. By integrating expertise and resources from diverse fields, we aim to address challenging, multifaceted research questions and uncover solutions that would remain elusive through conventional approaches.

Person infront of microscope.

LSX - First Call for Seed Grant Proposals

Life Science Technologies - LSX now calls for seed grant applications to promote interdisciplinary collaborations at LiU. Read more and apply.

Biointeractive molecular design

The targeting of enigmatic, complex disease systems with often highly disordered biological and structural properties severely suffers from slow progress due to the lack of appropriate research tools. By connecting expertise in molecular targeting with structural biology, biophysics, and novel sensing technologies we aim to invent, build, and tailor next-generation innovative methodologies to extend druggability and diagnostic options in cancer and neurodegenerative diseases.

Responsible PIs

petni61

Peter Nilsson

Professor

marsu05

Maria Sunnerhagen

Professor

Oligonucleotide nanocarrier systems

Therapeutic Oligonucleotides Activated by Nucleases (TOUCAN) offers new means for treatment of bacterial infections, cancers, and autoimmune diseases. We will combine advanced biophysical and electrochemical characterization techniques to facilitate and optimize the design of a TOUCAN-based oligo-conjugate-based prodrug activation and drug delivery systems. Structural characterization will be carried out by large-scale infrastructure measurements and molecular simulations to atomic resolution (MAX IV, SwedNMR, NAISS).

Responsible PIs

marsu05

Maria Sunnerhagen

Professor

edwja21

Edwin Jager

Professor, Head of Division

Brain stimulation and monitoring of nerve signals

Neurostimulation is important in health care but the mechanism behind nerve signal interaction with tissue is not fully understood. We aim to explore neurosignaling mechanisms from cell to organ by implementing data collection interface with the human brain to investigate the relationship between stimulation, neuron function and tissue microcirculation and biochemistry in critically ill patients. We will use this knowledge to design next-generation electrical and chemical neurostimulation/recording devices based on organic electronics to increase biocompatibility and expand existing functionality.

Responsible PIs

karwa46

Karin Wårdell

Professor

magbe98

Magnus Berggren

Professor

Bioelectronics: In vivo-templated substrate-free bioelectronics and ligand/devices for optoelectronic sensing

Bioelectronic technologies can provide groundbreaking insights regarding biological and pathological processes, as well as offer novel diagnostic and therapeutical inventions for distinct diseases. We aim to explore and expand on soft organic electronically conducting materials which can self-assemble at physiological conditions and imbue electronic functionality and develop optoelectronic ligands that can be utilized for optical or electronic recording of pathological events in different settings.

Responsible PIs

dansi08

Daniel Simon

Professor, Head of Unit

petni61

Peter Nilsson

Professor

Engineered skin tissue viability monitoring

Biofabricated skin can improve treatment outcome of burns and non-healing wounds but recreating the native skin architecture is highly challenging. We aim to develop novel skin biofabrication strategies and combined multiparametric imaging and optical monitoring techniques for characterization of engineered tissues and microcirculation during tissue regeneration.

Responsible PIs

danai11

Daniel Aili

Professor, Head of Unit

hanka60

Hanna Jonasson

Associate Professor

Bionic actuation of living biomaterials

Electromechanical actuation of soft living biomaterials can facilitate development of a wide range tissue engineering strategies. The aim of this project is to combine soft biomaterials with bionic actuation strategies to generate cell-containing hybrid materials for tissue engineering of e.g, biosynthetic bone, muscles, and blood vessels, that require mechanical actuation during tissue maturation and/or for proper function. We will develop new hybrid hydrogels for in vitro 3D culture that can be processed by 3D bioprinting and explore strategies for integration of bionic actuators for mechanostimulation to control tissue maturation and evaluate the engineered tissues in vitro and in vivo.

Responsible PIs

edwja21

Edwin Jager

Professor, Head of Division

danai11

Daniel Aili

Professor, Head of Unit

Fluorescing nanoprobes for brain tumor identification

5-ALA fluorescence can identify high grade brain tumors intraoperatively but not low-grade tumors. We aim to identify targeted fluorescent nanoprobes for identification of low-grade tumors and that also allow for increased precision in delineation of tumor marginal zone. Our long-term goal is high precision targeted fluorescent probes tailored for intraoperative navigation tools to maximize resection efficiency and improve survival outcomes.

Responsible PIs

kajuv09

Kajsa Uvdal

Professor, Head of Division

karwa46

Karin Wårdell

Professor

Contact persons for the profile area Life Science Technologies

 
danai11

Daniel Aili

Professor, Head of Unit
 
karwa46

Karin Wårdell

Professor

Tags