Molecular Ion Channels Physiology

Nerve cells are close to the threshold that makes them fire rapid nerve impulses.

A high or low threshold can cause epilepsy or pain. We study a new mechanism by which different substances can raise or lower the threshold by opening or closing the voltage activated ion channels.

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Malin Silverå Ejneby, Björn Wallner, Fredrik Elinder (2020)
Coupling stabilizers open KV1-type potassium channels

Proceedings of the National Academy of Sciences of the United States of America , Vol.117 , s.27016-27021 Continue to DOI

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018)
Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid

The Journal of General Physiology , Vol.150 , s.731-750 Continue to DOI

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017)
A drug pocket at the lipid bilayer-potassium channel interface

Science Advances , Vol.3 Continue to DOI

Sara Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, Fredrik Elinder (2015)
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I-Ks channel

Proceedings of the National Academy of Sciences of the United States of America , Vol.112 , s.5714-5719 Continue to DOI

Nina Ottosson, Sara I. Liin, Fredrik Elinder (2014)
Drug-induced ion channel opening tuned by the voltage sensor charge profile

The Journal of General Physiology , Vol.143 , s.173-182 Continue to DOI

Ulrike Henrion, Jakob Renhorn, Sara Börjesson, Erin M Nelson, Christine S Schwaiger, Par Bjelkmar, Björn Wallner, Erik Lindahl, Fredrik Elinder (2012)
Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America , Vol.109 , s.8552-8557 Continue to DOI

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Fredrik Elinder and a PhD student discussing in the lab.

New mechanism affecting nerve impulses discovered

Researchers at LiU have discovered a new mechanism by which substances can open a certain type of ion channel and in this way regulate nerve impulses. The discovery, published in the journal PNAS, may help in the development of future drugs. 
Nina Ottosson and Fredrik Elinder

Drug development – not only in industry

Neuroscientists obtain support from SciLifeLab when working to develop new drugs against epilepsy. The project is the first from Linköping University that has been accepted as a full program for the Drug Discovery and Development Platform (DDD).
Ali Moshfegh, Fredrik Elinder and Nina Ottosson laughing

From the lab to the clinic

Countless companies have been founded on a promising research result or a truly great idea. But what is needed in order to translate this into a product or service? Meet two researchers in neurobiology who have taken on the role of entrepreneur.

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