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Photo of Fredrik Elinder

Fredrik Elinder

Deputy Head of Department, Professor

Researcher in the field of voltage-gated ion channels.

Molecular Ion Channel Physiology

Nerve cells are close to the threshold that makes them fire rapid nervous impulses.

An altered threshold can cause epilepsy or pain. We study a new mechanism by which different substances can restore the threshold by opening or closing of voltage-gated ion channels.

Research

Molecular physiology of voltage-gated ion channels.

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.

SciLifeLab - a research infrastructure

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SciLifeLab Linköping

SciLifeLab Linköping is both a local and a national research infrastructure, with unique technologies and expert competence accessible for academic and industrial researcher in the field of life sciences, health and data-driven life science.

Publications

Selected publications

Malin Silverå Ejneby, Björn Wallner, Fredrik Elinder (2020)
Coupling stabilizers open KV1-type potassium channels

Proceedings of the National Academy of Sciences of the United States of America , Vol.117 , s.27016-27021

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Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018)
Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid

The Journal of General Physiology , Vol.150 , s.731-750

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Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017)
A drug pocket at the lipid bilayer-potassium channel interface

Science Advances , Vol.3

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Sara Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, Fredrik Elinder (2015)
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I-Ks channel

Proceedings of the National Academy of Sciences of the United States of America , Vol.112 , s.5714-5719

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Nina Ottosson, Sara I. Liin, Fredrik Elinder (2014)
Drug-induced ion channel opening tuned by the voltage sensor charge profile

The Journal of General Physiology , Vol.143 , s.173-182

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Ulrike Henrion, Jakob Renhorn, Sara Börjesson, Erin M Nelson, Christine S Schwaiger, Par Bjelkmar, Björn Wallner, Erik Lindahl, Fredrik Elinder (2012)
Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America , Vol.109 , s.8552-8557

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Co-workers

Research Group

Photo of Johan Brask

Johan Brask

Enhetschef, Principal Research Engineer

Photo of Argel Estrada Mondragón

Argel Estrada Mondragón

Principal Research Engineer

Photo of Urban Karlsson

Urban Karlsson

Principal Research Engineer

Photo of Nina Ottosson

Nina Ottosson

Senior Research Coordinator

Research Colleagues

Photo of Björn Granseth

Björn Granseth

Associate Professor, Docent

Photo of Anders Fridberger

Anders Fridberger

Deputy Dean, Professor

Photo of Peter Konradsson

Peter Konradsson
Photo of Sara Liin

Sara Liin

Senior Associate Professor

Photo of Antonios Pantazis

Antonios Pantazis

Senior Associate Professor

Organisation

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

The Division of Cell and Neurobiology (CNB)

The Division of Cell and Neurobiology is a dynamic and innovative environment where we conduct research and teaching on both the structure and function of various cells as well as the nervous system and sensory organs.