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Molecular Ion Channel Physiology

Nerve cells are close to the threshold that makes them fire rapid nervous impulses.

An altered threshold can cause epilepsy or pain. We study a new mechanism by which different substances can restore the threshold by opening or closing of voltage-gated ion channels.

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Selected publications

Malin Silverå Ejneby, Björn Wallner, Fredrik Elinder (2020)
Coupling stabilizers open KV1-type potassium channels

Proceedings of the National Academy of Sciences of the United States of America , Vol.117 , s.27016-27021 Continue to DOI

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018)
Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid

The Journal of General Physiology , Vol.150 , s.731-750 Continue to DOI

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017)
A drug pocket at the lipid bilayer-potassium channel interface

Science Advances , Vol.3 Continue to DOI

Sara Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, Fredrik Elinder (2015)
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I-Ks channel

Proceedings of the National Academy of Sciences of the United States of America , Vol.112 , s.5714-5719 Continue to DOI

Nina Ottosson, Sara I. Liin, Fredrik Elinder (2014)
Drug-induced ion channel opening tuned by the voltage sensor charge profile

The Journal of General Physiology , Vol.143 , s.173-182 Continue to DOI

Ulrike Henrion, Jakob Renhorn, Sara Börjesson, Erin M Nelson, Christine S Schwaiger, Par Bjelkmar, Björn Wallner, Erik Lindahl, Fredrik Elinder (2012)
Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America , Vol.109 , s.8552-8557 Continue to DOI

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Older man with chest pain during running.

SEK 17 million for cardiopulmonary research at LiU

Nine researchers at LiU have received research funding from the Swedish Heart Lung Foundation. The funded research will include work on the immune system in heart disease, the development of new drugs, and the effects of remote yoga on heart failure.
Fredrik Elinder.

Prize winner: “I realise how debilitating a disease epilepsy is”

Fredrik Elinder, professor in molecular neurobiology, has received the Onkel Adam Award for 2021 for his outstanding research in the Faculty of Medicine and Health Sciences at Linköping University.

Major infrastructure grants to researchers at LiU

Several projects at Linköping University are to receive grants for the development of research infrastructure. The total amount is of the order of a hundred million Swedish crowns, and decades of work are now bearing fruit.

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