Fredrik Elinder

Deputy Head of Department, Professor

Researcher in the field of voltage-gated ion channels.

Molecular Ion Channel Physiology

Nerve cells are close to the threshold that makes them fire rapid nervous impulses.

An altered threshold can cause epilepsy or pain. We study a new mechanism by which different substances can restore the threshold by opening or closing of voltage-gated ion channels.

Research

Molecular physiology of voltage-gated ion channels

Voltage-gated ion channels are key players in all biological systems where they generate and modulate for instance the nervous impulse and pacemaker activity in the heart and the brain.

SciLifeLab - a research infrastructure

Campus US with cherry blossom in the foreground.

SciLifeLab Linköping

SciLifeLab Linköping is both a local and a national research infrastructure, with unique technologies and expert competence accessible for academic and industrial researcher in the field of life sciences, health and data-driven life science.

Publications

Selected publications

Malin Silverå Ejneby, Björn Wallner, Fredrik Elinder (2020)

Coupling stabilizers open K_V1-type potassium channels

Proceedings of the National Academy of Sciences of the United States of America , Vol.117 , s.27016-27021

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Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018)

Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid

The Journal of General Physiology , Vol.150 , s.731-750

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Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017)

A drug pocket at the lipid bilayer-potassium channel interface

Science Advances , Vol.3

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Sara Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, Fredrik Elinder (2015)

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I-Ks channel

Proceedings of the National Academy of Sciences of the United States of America , Vol.112 , s.5714-5719

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Nina Ottosson, Sara I. Liin, Fredrik Elinder (2014)

Drug-induced ion channel opening tuned by the voltage sensor charge profile

The Journal of General Physiology , Vol.143 , s.173-182

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Ulrike Henrion, Jakob Renhorn, Sara Börjesson, Erin M Nelson, Christine S Schwaiger, Par Bjelkmar, Björn Wallner, Erik Lindahl, Fredrik Elinder (2012)

Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America , Vol.109 , s.8552-8557

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Co-workers

Research Group

Johan Brask

Enhetschef, Principal Research Engineer

Argel Estrada Mondragón

Principal Research Engineer

Urban Karlsson

Principal Research Engineer

Nina Ottosson

Senior Research Coordinator

Research Colleagues

Björn Granseth

Associate Professor, Docent

Anders Fridberger

Deputy Dean, Professor

Peter Konradsson

Sara Liin

Senior Associate Professor

Antonios Pantazis

Senior Associate Professor

News

Two researchers in a lab discuss a graph on a computer screen.

How molecules can ‘remember’ and contribute to memory

Researchers have discovered how an ion channel in the brain’s neurons has a kind of ‘molecular memory’, which contributes to the formation and preservation of lifelong memories.

Three men and a woman outside Campus US.

SciLifeLab establishes a new research site at LiU

Technology, expertise, methods and initiatives can be coordinated more within and between higher education institutions. Linköping University is now one of four new sites in the Swedish research infrastructure SciLifeLab.

Prize winner: “I realise how debilitating a disease epilepsy is”

Fredrik Elinder, professor in molecular neurobiology, has received the Onkel Adam Award for 2021 for his outstanding research in the Faculty of Medicine and Health Sciences at Linköping University.

Organisation

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

The Division of Cell and Neurobiology (CNB)

The Division of Cell and Neurobiology is a dynamic and innovative environment where we conduct research and teaching on both the structure and function of various cells as well as the nervous system and sensory organs.

Fredrik Elinder

Molecular Ion Channel Physiology

Research

Molecular physiology of voltage-gated ion channels