Molecular Ion Channels Physiology

Nerve cells are close to the threshold that makes them fire rapid nerve impulses.

A high or low threshold can cause epilepsy or pain. We study a new mechanism by which different substances can raise or lower the threshold by opening or closing the voltage activated ion channels.

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Malin Silverå Ejneby, Björn Wallner, Fredrik Elinder (2020)
Coupling stabilizers open KV1-type potassium channels

Proceedings of the National Academy of Sciences of the United States of America , Vol.117 , s.27016-27021 Continue to DOI

Malin Silverå Ejneby, Xiongyu Wu, Nina Ottosson, E Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder (2018)
Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid

The Journal of General Physiology , Vol.150 , s.731-750 Continue to DOI

Nina Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder (2017)
A drug pocket at the lipid bilayer-potassium channel interface

Science Advances , Vol.3 Continue to DOI

Sara Liin, Malin Silverå Ejneby, Rene Barro-Soria, Mark Alexander Skarsfeldt, Johan Larsson, Frida Starck Härlin, Teija Parkkari, Bo Hjorth Bentzen, Nicole Schmitt, H. Peter Larsson, Fredrik Elinder (2015)
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I-Ks channel

Proceedings of the National Academy of Sciences of the United States of America , Vol.112 , s.5714-5719 Continue to DOI

Nina Ottosson, Sara I. Liin, Fredrik Elinder (2014)
Drug-induced ion channel opening tuned by the voltage sensor charge profile

The Journal of General Physiology , Vol.143 , s.173-182 Continue to DOI

Ulrike Henrion, Jakob Renhorn, Sara Börjesson, Erin M Nelson, Christine S Schwaiger, Par Bjelkmar, Björn Wallner, Erik Lindahl, Fredrik Elinder (2012)
Tracking a complete voltage-sensor cycle with metal-ion bridges

Proceedings of the National Academy of Sciences of the United States of America , Vol.109 , s.8552-8557 Continue to DOI

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New mechanism affecting nerve impulses discovered

Researchers at LiU have discovered a new mechanism by which substances can open a certain type of ion channel and in this way regulate nerve impulses. The discovery, published in the journal PNAS, may help in the development of future drugs. 

Drug development – not only in industry

Neuroscientists obtain support from SciLifeLab when working to develop new drugs against epilepsy. The project is the first from Linköping University that has been accepted as a full program for the Drug Discovery and Development Platform (DDD).
Ali Moshfegh, Fredrik Elinder and Nina Ottosson laughing

From the lab to the clinic

Countless companies have been founded on a promising research result or a truly great idea. But what is needed in order to translate this into a product or service? Meet two researchers in neurobiology who have taken on the role of entrepreneur.

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