Integrative Systems Biology (ISB)

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments.

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Current projects

Finished projects

Publications

2025

Wile Balkhed, Martin Bergram, Fredrik Iredahl, Markus Holmberg, Carl Edin, Carljohan Carlhäll, Tino Ebbers, Pontus Henriksson, Christian Simonsson, Karin Rådholm, Gunnar Cedersund, Mikael Forsgren, Olof Dahlqvist Leinhard, Cecilia Jönsson, Peter Lundberg, Stergios Kechagias, Nils Dahlström, Patrik Nasr, Mattias Ekstedt (2025) Evaluating the prevalence and severity of metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus in primary care Journal of Internal Medicine (Article in journal) Continue to DOI
Alejandro Garcia-Rudolph, Sergiu Albu, Mark Andrew Wright, Maria del Mar Laya, Claudia Teixido, Eloy Opisso, Gunnar Cedersund, Montserrat Bernabeu (2025) Characterization, Outcomes, and Time to Event Predictors of Urinary Tract Infections Acquired During Postacute Stroke Inpatient Rehabilitation: A Comprehensive Cohort Study Archives of Physical Medicine and Rehabilitation, Vol. 106, p. 729-737 (Article in journal) Continue to DOI
Belén Casas Garcia, Kajsa Tunedal, Federica Viola, Gunnar Cedersund, Carljohan Carlhäll, Matts Karlsson, Tino Ebbers (2025) Observer- and sequence variability in personalized 4D flow MRI-based cardiovascular models Scientific Reports, Vol. 15, Article 1352 (Article in journal) Continue to DOI
Alejandro Garcia-Rudolph, Mark Andrew Wright, Claudia Teixido, Eloy Opisso, Gunnar Cedersund, Josep Medina (2025) Efficiency of telerehabilitation on subacute stroke ambulation: a matched case-control study BRAIN IMPAIRMENT, Vol. 26, Article IB24032 (Article in journal) Continue to DOI

2024

Nina Grankvist, Cecilia Jönsson, Karin Hedin, Nicolas Sundqvist, Per A Sandström, Bergthor Björnsson, Arjana Begzati, Evgeniya Mickols, Per Artursson, Mohit Jain, Gunnar Cedersund, Roland Nilsson (2024) Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo Nature Metabolism, Vol. 6, p. 1963-1975 (Article in journal) Continue to DOI
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Mullers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Lofmark, Carina Ammala, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilen (2024) Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system Communications Biology, Vol. 7, Article 877 (Article in journal) Continue to DOI
Christian Simonsson, Elin Nyman, Peter Gennemark, Peter Gustafsson, Ingrid Hotz, Mattias Ekstedt, Peter Lundberg, Gunnar Cedersund (2024) A unified framework for prediction of liver steatosis dynamics in response to different diet and drug interventions Clinical Nutrition, Vol. 43, p. 1532-1543 (Article in journal) Continue to DOI
Gustav Magnusson, Maria Engström, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Anders Tisell (2024) High inspired CO<sub>2</sub> target accuracy in mechanical ventilation and spontaneous breathing using the Additional CO<sub>2</sub> method Frontiers in Medicine, Vol. 11, Article 1352012 (Article in journal) Continue to DOI
Henrik Podéus, Christian Simonsson, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg, William Lövfors, Gunnar Cedersund (2024) A physiologically-based digital twin for alcohol consumption-predicting real-life drinking responses and long-term plasma PEth npj Digital Medicine, Vol. 7, Article 112 (Article in journal) Continue to DOI

2023

Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman (2023) Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation Journal of Biological Chemistry, Vol. 299, Article 105205 (Article in journal) Continue to DOI

Latest student publications

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