Integrative Systems Biology (ISB)

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments. 

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Current projects

Finished projects

Publications

2023

Niloofar Nikaein, Kedeye Tuerxun, Gunnar Cedersund, Daniel Eklund, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Dirk Repsilber, Alexander Persson, Elin Nyman (2023) Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation Journal of Biological Chemistry, Vol. 299, Article 105205 Continue to DOI
Christian Simonsson, William Lövfors, Niclas Bergqvist, Elin Nyman, Peter Gennemark, Karin G. Stenkula, Gunnar Cedersund (2023) A multi-scale in silico mouse model for diet-induced insulin resistance Biochemical engineering journal, Vol. 191, Article 108798 Continue to DOI
William Lövfors, Rasmus Magnusson, Cecilia Jönsson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman (2023) A comprehensive mechanistic model of adipocyte signaling with layers of confidence NPJ SYSTEMS BIOLOGY AND APPLICATIONS, Vol. 9, Article 24 Continue to DOI
Tilda Herrgårdh, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Karin G. Stenkula, Elin Nyman, Peter Gennemark, Gunnar Cedersund (2023) A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects Diabetology and Metabolic Syndrome, Vol. 15, Article 250 Continue to DOI

2022

William Lövfors, Cecilia Jönsson, Charlotta S. Olofsson, Elin Nyman, Gunnar Cedersund (2022) A comprehensive mechanistic model of adipocyte signaling with layers of confidence

2021

William Lövfors, Jona Ekström, Cecilia Jönsson, Peter Strålfors, Gunnar Cedersund, Elin Nyman (2021) A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo PLOS ONE, Vol. 16, Article e0261681 Continue to DOI
William Lövfors, Christian Simonsson, Ali M. Komai, Elin Nyman, Charlotta S. Olofsson, Gunnar Cedersund (2021) A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes Journal of Biological Chemistry, Vol. 297, Article 101221 Continue to DOI
Tilda Herrgårdh, Hao Li, Elin Nyman, Gunnar Cedersund (2021) An Updated Organ-Based Multi-Level Model for Glucose Homeostasis: Organ Distributions, Timing, and Impact of Blood Flow Frontiers in Physiology, Vol. 12, Article 619254 Continue to DOI

2020

Elin Nyman, Maria Lindh, William Lövfors, Christian Simonsson, Alexander Persson, Daniel Eklund, Erica Backstrom, Markus Friden, Gunnar Cedersund (2020) Mechanisms of a Sustained Anti-inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling CPT: Pharmacometrics and Systems Pharmacology (PSP), Vol. 9, p. 707-717 Continue to DOI

2017

Elin Nyman, Stefano Bartesaghi, Rebecka Melin Rydfalk, Sandra Eng, Charlotte Pollard, Peter Gennemark, Xiao-Rong Peng, Gunnar Cedersund (2017) Systems biology reveals uncoupling beyond UCP1 in human white fat-derived beige adipocytes NPJ systems biology and applications, Vol. 3, Article 29 Continue to DOI

Latest student publications

Group leader

Organisation