Overall aim of the NACOX study is to investigate the natural corollaries and recovery after an ACL injury.
There are five main study objectives:
- To assess biological, psychological and social factors and their relationships to the natural corollaries and recovery after acute ACL injury
- To evaluate the choice of treatment after acute ACL-injury (i.e. ACL reconstruction, ACLR or non-ACL reconstruction, non-ACLR)
- To evaluate the return to sport after acute ACL injury
- To study knee problems in the short and long term after acute ACL-injury
- To identify proxies (biomarkers and structural risk factors) for early detection of symptomatic and radiographic osteoarthritis
This is a multi-centre prospective prognostic cohort study of patients with acute ACL injury. At 7 sites in Sweden, patients aged 15-40 years are included within 6 weeks after primary ACL injury. Patients complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 131 patients are followed with clinical examinations, several imaging modalities, and biological samples.
The last patient was included 15th October 2019. In total, 142 patients have been included from Linköping and 136 from the other sites together.