22 February 2024

Men who were physically fit when they were young had a lower risk of atherosclerosis almost 40 years later, according to a study led by researchers at Linköping University. The findings, published in the British Journal of Sports Medicine, suggest that atherosclerosis is one of the mechanisms behind the link between physical fitness and cardiovascular disease.

young man taking a break from running.The research team investigated the relationship between physical fitness and atherosclerosis later in life. Photo credit Maridav “Our results strengthen the notion that physical fitness is linked to health outcomes much later in life. The findings are worrying in the sense that there is a clear global trend indicating that young people are less fit now than when these study participants were young in the 1970s and 80s. Therefore, I believe that these findings may be even more important for those growing up now,” says Pontus Henriksson, senior associate professor at the Department of Health, Medicine and Caring Sciences at Linköping University.Pontus Henriksson.Pontus Henriksson. Photo credit Emma Busk Winquist

It is well-known that being physically unfit at a young age is linked to an increased risk of cardiovascular disease much later in life. But the mechanism behind this finding is not fully understood. An important risk marker for future cardiovascular disease is the occurrence of atherosclerosis, which involves the accumulation of plaques in the arteries. The international research team behind the current study therefore wanted to investigate whether physical fitness in adolescence is linked to atherosclerosis much later, which in that case would indicate that atherosclerosis is a likely mechanism behind the observed link to cardiovascular disease.

State-of-the-art technology

In the study, the researchers linked information from the Swedish Military Conscription Register to SCAPIS (the Swedish Cardiopulmonary Bioimage Study), a large population study on heart and lung health in individuals aged 50 to 64 years. For almost 9,000 men who participated in SCAPIS, data on them at conscription at age 18 from 1972 to 1987 were also available. One of the strengths of the study is that it is based on the general population and that the men have been followed for a long time, an average of 38 years.

The researchers examined the coronary arteries, which supply blood to the heart muscle, using coronary CT angiography, CCTA. The study is the first to use this state-of-the-art technology to examine plaques in the coronary arteries in relation to physical fitness at a young age. In addition, the researchers studied two different types of plaques in the coronary arteries. Plaques with calcium deposits are easy to measure and have long been the focus.Headshot of a man.Angel Herraiz-Adillo, postdoc.

“We measured not only calcified plaques in the coronary arteries, but also non-calcified plaques, which are considered more problematic. They may be more likely to rupture, which can cause heart attacks, and have a worse prognosis,” says Ángel Herraiz-Adillo, postdoc in the same research group.

Difference 40 years later

“We see in our study that both good cardiorespiratory fitness and good muscle strength in youth are associated with a lower risk of atherosclerosis in the coronary arteries almost 40 years later,” says Pontus Henriksson.

The researchers also examined atherosclerosis in the large arteries from the heart up to the brain with ultrasound.

Since only men did military service in Sweden at the time, the researchers have only been able to investigate the association between physical fitness and atherosclerosis in men. It is therefore not possible to draw conclusions for women from this particular study.

The study was funded by, among others, the Heart-Lung Foundation, which is the main funder of SCAPIS, the Knut and Alice Wallenberg Foundation, the Swedish Research Council, Vinnova and the Joanna Cocozza Foundation for Children’s Medical Research. Several other researchers from Linköping University also participated in the work on the study: Karin Rådholm, Carl Johan Östgren, Kristofer Hedman and Sara Higueras-Fresnillo.

Article: Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study, Ángel Herraiz-Adillo, Viktor H Ahlqvist, Sara Higueras-Fresnillo, Kristofer Hedman, Emil Hagström, Melony Fortuin-de Smidt, Bledar Daka, Cecilia Lenander, Daniel Berglind, Carl Johan Östgren, Karin Rådholm, Francisco B Ortega and Pontus Henriksson, Br J Sports Med, published online 14 February 2024, doi: 10.1136/bjsports-2023-107663

Translation by Anneli Mosell


What is atherosclerosis?

  • Atherosclerosis means that plaque (composed of fat, cholesterol, calcium and other substances) accumulates in the arterial walls, causing them to narrow. High blood pressure, high blood lipids, diabetes and smoking can speed up the process.
  • Over time, plaque buildup in the coronary arteries can narrow them, reducing blood flow to the heart and causing chest pain known as angina.
  • The plaques can also break and cause blood clots, heart attacks or strokes.
    Sources: 1177.se, Ángel Herraiz-Adillo, postdoc, and Pontus Henriksson, senior associate professor, both at Linköping University.


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