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Jonas Wetterö

Senior Associate Professor

Senior Associate Professor of Immunology and Docent of Experimental Rheumatology. Director of Studies.

Inflammatory mediators in rheumatic diseases

Research

The overall aim of the research is to obtain an enhanced understanding of inflammation for the benefit of patients with inflammatory diseases, mainly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). To accomplish this, we perform experimental studies in acute inflammation and innate immunology to target inflammatory mediators.
Key areas include the biological roles and synthesis regulation of acute phase proteins (including complement), autoantibodies, immune complexes, leukocyte respiratory burst reactions/frustrated phagocytosis, and platelets in inflammation.
In addition I have a long standing interest in biointerphases and biosensors.

Teaching

I am Director of Studies for a handful of courses for civil engineering students (Engineering Biology and Chemical Biology), and examiner for courses in, for example, Immunology and Cell Biology, and for Degree Projects.

Publications

2025

Jesper Karlsson, Lina Wirestam, Hanna Duan, Suhana Ahmad, Daniel Appelgren, Helena Enocsson, Jonas Wetterö, Christopher Sjöwall (2025) Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation Frontiers in Immunology, Vol. 16, Article 1578372 (Article in journal) Continue to DOI

2024

Cecilia Hemgren, Klara Martinsson, Christopher Rooney, Jonas Wetterö, Kulveer Mankia, Paul Emery, Alf Kastbom (2024) Elevated Serum Levels of Zonulin Family Peptides in Anticitrullinated Protein Antibody-Positive At-Risk Individuals Without Arthritis Journal of Rheumatology, Vol. 51, p. 134-138 (Article in journal) Continue to DOI

2023

Per Lewander, Lina Wirestam, Charlotte Dahle, Jonas Wetterö, Christopher Sjöwall (2023) Serum levels of soluble urokinase plasminogen activator receptor in juvenile idiopathic arthritis: a single-center Swedish case-control study Pediatric Rheumatology, Vol. 21, Article 49 (Article in journal) Continue to DOI
Lina Wirestam, Frida Jönsson, Helena Enocsson, Christina Svensson, Maria Weiner, Jonas Wetterö, Helene Zachrisson, Per Eriksson, Christopher Sjöwall (2023) Limited Association between Antibodies to Oxidized Low-Density Lipoprotein and Vascular Affection in Patients with Established Systemic Lupus Erythematosus International Journal of Molecular Sciences, Vol. 24, Article 8987 (Article in journal) Continue to DOI
Cecilia Svanberg, Helena Enocsson, Melissa Govender, Klara Martinsson, Lawrence A. Potempa, Ibraheem M. Rajab, Rafael Fernandez-Botran, Jonas Wetterö, Marie Larsson, Christopher Sjöwall (2023) Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type I interferon gene dysregulation Journal of Autoimmunity, Vol. 135, Article 102998 (Article in journal) Continue to DOI

News

Blood sampling in clinical setting from finger.

C-reactive protein reduces immune response in inflammatory disease

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers now show that this protein has a beneficial function in SLE, an inflammatory disease. But this is true only for one of CRP’s two forms, according to the study.

Related research

Ingrid Asp Kidney Research Center

Two researchers working in a lab.

The Nestor Lab

Our research aims to understand the function of DNA methylation in the biology of human CD4+ T-cells, and use this knowledge to dissect its role in disease.

Organisation

Department of Biomedical and Clinical Sciences (BKV)

What characterizes the Department of Biomedical and Clinical Sciences (BKV) is the wide breadth of research and education. BKV is one of the largest departments at LiU with affiliation mainly to the Faculty of Medicine and Health Sciences.

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