Teknikplattformar

Följande teknikplattformar finns att tillgå vid Centrum för systemneurobiologi. Beskrivande text endast på engelska. För mer information, kontakta respektive kontaktperson.

Neuroimaging techniques

The neuroimaging platform offers services in designing neuroimaging studies, setting up experimental protocols, and advising in the preprocessing and analysis of data acquired from several neuroimaging modalities.

Areas of expertise include functional magnetic resonance imaging (MRI), structural MRI, diffusion-weighted imaging (a.k.a. DTI), quantitative MRI, blood-perfusion imaging and magnetic resonance spectroscopy. For task-based functional MRI studies we have equipment for automated presentation of visual, auditory, tactile, and olfactory stimuli.

We also have capabilities for conducting simultaneous functional MRI and electroencephalography. We are now developing and testing electromyographic methods for measuring facial-emotion response during functional MRI scans.

Contact person:
Paul Hamilton
E-mail: paul.hamilton@liu.se

 

Drug discovery platform

The drug discovery platform offer facilities in synthesis of small molecule compounds for target identification, lead identification and lead optimization.
Our skills include multiple-step synthesis, synthesis for SAR investigation, up scaling from mg to g, synthetic route optimization, and structural elucidation of metabolite. We have a lot of experience in the synthesis of natural product and its derivatives, carbohydrate, stilbene, heterocyclic compounds, i.e. oligothiophene, resveratrol, terpene and its derivatives.

Contact person:
Xiongyu Wu, IFM, 3B:590
E-mail: xiowu@ifm.liu.se
Tel: 013-28 46 66

Electrophysiology platform

Within the electrophysiology platform, the patch clamp technique is used to record electrical activity in slices of brain and spinal cord, as well as in primary cultures and cell lines.
There is also the possibility to do simultaneous calcium imaging studies and to identify neuronal populations expressing fluorescent proteins. 
Examples are studies of neuronal excitability, inhibitory and excitatory synaptic transmission and drug effects on ligand- and voltage-gated ion channels.

Contact person:
Urban Karlsson, Cell Biology floor 11
E-mail: urban.karlsson@liu.se
Tel: 010-103 07 51

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