Infrastructures

SciLifeLab technologies at LiU

SciLifeLab has local activities in Linköping. Our goal is to visualize these and make them accessible to local and national researchers and to facilitate communication between SciLifeLab and the local research infrastructure in Linköping.

AIDA Data Hub

AIDA Data Hub offers data and services to support the Swedish research and innovation community in medical imaging diagnostics AI. Two male and one female researchers in research environment.Caroline Bivik Stadler, Claes Lundström and Joel Hedlund at AIDA, Linköping University. Photo credit Ulrik Svedin The purpose is to gather, annotate, and share large volumes of data necessary to enable research, innovation and clinical adoption of world-class AI technology.

AIDA Data Hub is part of the Analytic Imaging Diagnostics Arena (AIDA) and of the SciLifeLab Bioinformatics Platform (NBIS). AIDA Data Hub also leads the development of the repository infrastructure for the European flagship project Bigpicture. AIDA Data Hub is coordinated by the Center for Medical Image Science and Visualization (CMIV) at Linköping University, and is funded by SciLifeLab.

Personnel

Joel Hedlund, Head of Unit 

Claes Lundström, Platform scientific director

Betül Eren, Data sharing

Caroline Bivik Stadler, AIDA Project leader

Emre Balsever, System developer

Erik Ylipää, AI research support

Pontus Freyhult, IT Architect

Varshith Konda, systemutvecklare

Chemical Biology Consortium Sweden (CBCS)

Chemical Biology Consortium Sweden (CBCS) provide expert support and experimental resources within assay development, computational chemistry, cheminformatics, chemical library screening and development, medicinal/synthetic chemistry and target identification. In addition, the CBCS are hosting the SciLifeLab Compound Collection of ca 350,000 molecules.Maria Lerm in the laboratoryProfessor Maria Lerm is searching for new ways to stop tuberculosis. Photo credit David Einar

CBCS works according to a collaborative research model based on mutual commitment from our group and the involved investigator.
For more substantial projects, a formal process initiated by an application is implemented to ensure that resources are prioritized based on transparent criteria, such as scientific excellence, novelty, technical feasibility, and relevance. Our Project Review Committee (PRC) consists of CBCS-independent experts in the chemical biology research field, also including industry representation.

The CBCS Linköping unit offers services within two areas: Electrophysiology and Screening in biosafety level 2 and 3 environments.

Personnel

Maria Lerm, professor, Head of Unit

Fredrik Elinder, professor

Nina Ottosson, doctor, staff scientist and expert in automated patch clamp

Sadaf Kalsum, expert in experimental microbiology with BSL2 -and BSL3 pathogens

Eva Danielson, expert in IncuCyte analysis techniques and AI-driven image analysis

Clinical Genomics Linköping

Clinical Genomics Linköping is one of seven Clinical Genomics units within the Clinical Genomics SciLifeLab platform. Clinical Genomics was established to facilitate the translation of new high-throughput (HTP) techniques, such as next-generation sequencing (NGS), into clinical use. This platform integrates technological, bioinformatics and clinical expertise to facilitate the application of HTP genomics in diagnostics. DNA-helix. An important aim for the platform is to disseminate up-to-date information about established assays/protocols and hence serve as a national competence center for HTP analysis in collaboration with hospitals and public health organizations. The Clinical Genomics platform lay the foundation for Genomic Medicine Sweden (GMS), with the aim to give patients all over Sweden access to large-scale genomic analyses and thereby improve diagnostics and individualized treatment.

Clinical Genomics Linköping is organized at the Faculty of Medicine and Health Sciences and operates in close collaboration with the clinical NGS platform at the University hospital in Linköping forming the local Genomic Medicine Sweden node GMC-southeast. Clinical Genomics Linköping provides a research hub and infrastructure for molecular genetic analyses serving basic and clinical scientists. It has organized its services around focus areas including cancer, rare diseases, complex diseases, and microbiology translating research to the clinical setting and implementation in health care.

Personnel

Peter Söderkvist, Platform Scientific Director

Tobias Strid, Head of unit

Jyotirmoy Das, Bioinformatician

Massimiliano Volpe, Bioinformatician

Åsa Schippert, Biomedical Laboratory Scientist

Mouna Tababi, Research Engineer

Bioinformatics platform (NBIS)

NBIS, National Bioinformatics Infrastructure Sweden, is a distributed national research infrastructure. We are the SciLifeLab bioinformatics platform and the Swedish node in Elixir, a European intergovernmental organization bringing together life science resources from across Europe. With over a hundred staff members, we work with bioinformatics support, infrastructure and training.

NBIS provide expertise in most areas of bioinformatics, including omics analysis, genome assembly/annotation, image analysis and biostatistics. We also offer support in systems development, such as interactive websites and data processing pipelines.Code for bioinformatics. Photo credit Mopic

NBIS is mainly funded by the Swedish Research Council, SciLifeLab, the Knut and Alice Wallenberg Foundation, and Swedish universities.
NBIS has staff at six sites: Göteborg, Linköping, Lund, Stockholm, Uppsala, and Umeå. In Linköping NBIS is represented by two bioinformaticians and AIDA data hub.

We provide:

  • Weekly online drop-in sessions. Join to discuss study design, data analysis or other bioinformatics-related questions.
  • Free consultation meetings to discuss study design.
  • Hands-on project support, ranging from assistance with smaller tasks to long-term engagement.
  • Free, extensive hands-on support to a limited set of projects selected in a peer review process (enabled by a grant from Knut and Alice Wallenberg Foundation).
  • Tools, data management, systems development, and guidelines for the life science community.
  • Introductory and advanced training events.
  • A mentorship program for PhD students interested in guidance from a bioinformatics expert.

For more information and to apply for support from NBIS, please visit www.nbis.se

Personnel

Malin Larsson, Principal Research Engineer

Claudio Mirabello, Principal Research Engineer

The National Infrastructure for Nuclear Magnetic Resonance (NMR)

The Swedish Nuclear Magnetic Resonance (SwedNMR) Centre provides access to state-of-the-art NMR instrumentation and methodology. SwedNMR provides access to NMR instrumentation and expertise within biomolecular NMR, materials NMR and translational NMR. All access to NMR equipment at LiU is made through the Protein folding and ligand interaction Core facility (ProLinC).

Services

Slow-to-fast protein dynamics characterization (CEST, CPMG relax-disp, R1ρrelax-disp, R1, R2, hetNOE)

Assignment of large proteins and interaction mapping w proteins and molecules

Intrinsically disordered proteins and their interactions with proteins and small molecules

Organic synthesis: analysis and structure evaluation

Equipment

500 mHz and 600 Mhz Consoles, Varian INOVA with 4 channels

Isak Johansson-Åkhe, Björn Wallner, Maria Sunnerhagen och Alexandra Ahlner intill NMR-utrustningen.Isak Johansson-Åkhe, Björn Wallner, Maria Sunnerhagen och Alexandra Ahlner intill NMR-utrustningen. Foto Charlotte Perhammar

Personnel

Maria Sunnerhagen, professor, Head of unit

Alexandra Ahlner, PhD, protein expert

Xiongyu Wu, PhD, small molecules expert

Marcus Bäck, PhD, small molecules expert

National infrastructures

SciLifeLab Linköping aims to connect local researchers with the national infrastructures at SciLifeLab.

Research infrastructure at other sites

SciLifeLab is available nationally at all major universities in Sweden. All sites and universities provide unique equipment and expert knowledge for users in Sweden and also internationally. Selected facilities are located at several universities, such as Clinical Genomics and NBIS.

 

SciLifeLab Gothenburg

In Gothenburg, SciLifeLab is located at the University of Gothenburg and at Chalmers University of Technology, and has a strong connection to Sahlgrenska University Hospital. Eight of SciLifeLab's ten technical platforms are represented here. NBIS has locally based bioinformaticians and Clinical Genomics Gothenburg provides sequencing and bioinformatics support for clinical researchers. Advanced mass spectrometry is used at the Swedish Metabolomics Center and the Glycoproteomics Unit.
At the University of Gothenburg, it is possible to do advanced correlative light and electron microscopy and screening for Cryo-EM. The Swedish NMR Center has spectrometers for, among other things, structural biology, metabolomics and interaction studies. The NMR center also has staff from Chemical Biology Consortium Sweden. Chalmers is responsible for the Data Science Node for the DDLS area of Cell and Molecular Biology. The OligoNova Hub is a unit for drug development, with a focus on oligonucleotides.

SciLifeLab Göteborg

 

 

Map over cities were SciLifeLab are.Map over cities were SciLifeLab are.  

 

SciLifeLab Lund

At Lund University, there are five of SciLifeLab's ten platforms, with a focus on different research areas, such as genomics, structural biology, drug development and bioinformatics. At Clinical Genomics Lund, there are experts from Lund University and Region Skåne who provide a translational next-generation sequencing-based service. At the unit for Human Antibody Therapeutics, there is knowledge to support research projects that develop antibodies for therapeutic purposes. NBIS has bioinformaticians in Lund who, like all NBIS bioinformaticians, work in a network for full national service.

SciLifeLab Lund

SciLifeLab Umeå

In Umeå there are seven SciLifeLab platforms distributed across Umeå University, Umeå University Hospital and the Swedish University of Agricultural Sciences. Clinical Genomics Umeå has clinical laboratories where, among other things, ultra-sensitive gene variant detection can be carried out and users can receive support with clinical interpretation of variants. At the Umeå Center for Electron Microscopy there is the Cryo-EM unit and the Focused Ion-Beam Scanning Electron Microscopy Volume Imaging node. Here is the Swedish Metabolomics Centre, CBCS Umeå which is part of SciLifeLab's infrastructure for chemical biology, local bioinformaticians for NBIS and the Swedish NMR Centre. In 2023, there will be a laboratory for visitors who need to prepare samples on site.

SciLifeLab Umeå

SciLifeLab Uppsala

Uppsala, with the two universities Uppsala University and the Swedish University of Agricultural Sciences provides a wide range of technologies and experts within eight of SciLifeLab's platforms. Here, in addition to laboratories, there is a central meeting place, Navet, located in the middle of the Biomedical Center (BMC). Here, researchers, unit employees and visitors can meet in small and large constellations in an inspiring environment. Uppsala University is one of the four host universities where SciLifeLab started.

SciLifeLab Uppsala Navet

SciLifeLab Stockholm Campus Solna

In Stockholm there are three of the four host universities at SciLifeLab; Karolinska Institutet with extensive operations and laboratories in the alpha and gamma buildings on Campus Solna near Karolinska University Hospital, Stockholm University and KTH Royal Institute of Technology. The proximity to a large range of facilities and knowledge invites networking between scientific fields.

SciLifeLab Stockholm Campus Solna

SciLifeLab i Örebro

In a collaboration between Örebro University and Örebro University Hospital, there is the SciLifeLab unit Clinical Genomics Örebro. Clinical microbiology in Örebro is part of the SciLifeLab Capability Pandemic Laboratory Preparedness.

Clinical Genomics Örebro 

Other infrastructures at LiU

SciLifeLab Linköping is a communication channel between SciLifeLab researchers and other research infrastructures and strong centers at LiU. SciLifeLab Linköping strives to connect LiU with important national infrastructures.