“Mimicking the behaviour of biological neurons has long been a major goal in so-called neuromorphic engineering. Traditional silicon-based electronics fall short because they don’t speak the same language as the nerve cells in our body,” says Simone Fabiano, professor of materials science at Linköping University, LiU.
Instead of relying on rigid silicon, Simone Fabiano’s team at the Laboratory of Organic Electronics at LiU works with a class of soft, flexible materials called conjugated polymers that can transport both ions and electrons. This dual capability allows them to interface more closely with biological systems.
Add a sense of touch to robotics
In an article published in Science Advances, Simone Fabiano’s research group has shown that their artificial neurons can perform a type of information processing observed in our nervous system. This function means the neuron activates only when one input is present and another is absent. It is called anticoincidence detection and is a core principle in tasks like tactile sensing.
“We can imagine using these devices to add a sense of touch in prosthetics or robotics. They show that organic electronics are not just softer alternatives to silicon, but can enable new kinds of neural computing that connect biology with electronics,” says Simone Fabiano.
In parallel with developing advanced functionality, his research group has also worked to simplify the basic structure of these artificial neurons.
Small but capable
In early 2023, the researchers at Campus Norrköping succeeded in creating artificial nerve cells that reproduced 15 of the 22 key properties of biological neurons. However, those plastic nerve cells relied on many different components, which limited their practical use.
Now, in a study published in Nature Communications, the team has further refined the technology. They have reduced the artificial nerve cell to just a single organic electrochemical transistor, while still reproducing as many as 17 neural properties. This artificial neuron is not only highly functional but also extremely compact, comparable in size to a human nerve cell.
“This is one of the simplest and most biologically relevant artificial neurons made to date. It opens the door to integrating synthetic neurons directly with living tissue or soft robots,” says Simone Fabiano.
The research was mainly supported by the Knut and Alice Wallenberg Foundation, the European Research Council, the Swedish Research Council, and the Swedish Foundation for Strategic Research and through the Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials (AFM) at Linköping University.
Articles:
Single organic electrochemical neuron capable of anticoincidence detection, Padinhare Cholakkal Harikesh, Dace Gao, Han-Yan Wu, Chi-Yuan Yang, Deyu Tu, Simone Fabiano, Science Advances 2025, published online 20 June 2025. DOI: 10.1126/sciadv.adv3194
Single-transistor organic electrochemical neurons, Junpeng Ji, Dace Gao, Han-Yan Wu, Miao Xiong, Nevena Stajkovic, Claudia Latte Bovio, Chi-Yuan Yang, Francesca Santoro, Deyu Tu, Simone Fabiano, Nature Communications 2025, published online 9 May 2025. DOI: 10.1038/s41467-025-59587-4
