Fotografi av Anders Blomqvist

Anders Blomqvist

Professor emeritus

Mechanisms of immune-to-brain signaling

Peripheral inflammatory processes elicit a number of CNS mediated sickness responses, including fever, fatigue, depression, anorexia, social avoidance, and increased stress hormone release. We examine the mechanisms by which peripheral immune signals are monitored by the brain to elicit these symptoms, and in particular how these signals can circumvent the blood-brain barrier.

Using genetically modified mice with cell or tissue specific deletions of molecules involved in the inflammatory signaling cascade, or animals in which these molecules are selectively expressed in some cells/tissues, we study how peripherally released proinflammatory molecules activate blood-barrier cells, both in whole-body experiments and ex vivo in identified and isolated cells obtained by cell sorting techniques.

Using fever as a primary physiological read-out, being a readily monitored, quantifiable and standardized response to inflammation, we examine how peripherally released cytokines activate intracellular pathways that trigger prostaglandin synthesis, and we examine how the interaction between pyrogenic and cryogenic signals shape the temperature response to the immune challenge.

In a second associated line, we examine how peripheral inflammation as well as tumor generated messengers influence food intake and metabolism. Our work has implications for our understanding of the central processes involved in responding to acute and chronic peripheral inflammation and for finding novel treatments for the associated disease symptoms.

Postdoktorala tjänster tillgängliga

En 2-årig postdoktorandtjänst är ledig i mitt laboratorium

Den idealiska kandidaten bör ha en doktorsexamen i immunologi, neurovetenskap eller relaterade områden; djupgående laboratorieerfarenhet av att utföra oberoende forskning; goda kunskaper om molekylär och beteendemässig neurovetenskap, inklusive smådjursexperiment; och utmärkt engelsk tal- och skrivförmåga.

För att ansöka, skicka ett fullständigt CV, en kort sammanfattning av aktuell forskning, samt namn och kontaktinformation från två referenser till anders.blomqvist@liu.se

Publikationer

Utvalda publikationer

Omslag för publikation ''
Kiseko Shionoya, Anna Eskilsson, Anders Blomqvist (2022)

Proceedings of the National Academy of Sciences of the United States of America , Vol.119 Vidare till DOI

Omslag för publikation ''
Anna Eskilsson, Kiseko Shionoya, Sven Enerback, David Engblom, Anders Blomqvist (2020)

The FASEB Journal , Vol.34 , s.5863-5876 Vidare till DOI

Omslag för publikation ''
Anders Blomqvist, David Engblom (2018)

The Neuroscientist , Vol.24 , s.381-399 Vidare till DOI

Omslag för publikation ''
Anna Eskilsson, Takashi Matsuwaki, Kiseko Shionoya, Elahe Mirrasekhian, Joanna Zajdel, Markus Schwaninger, David Engblom, Anders Blomqvist (2017)

Journal of Neuroscience , Vol.37 , s.5035-5044 Vidare till DOI

Senaste publikationer i LiU DiVA

2024

Anders Blomqvist (2024) Inflammation-induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus Acta Physiologica (Artikel i tidskrift) Vidare till DOI
Irina A. Strigo, David Andrew, Alan N. Simmons, Henry C. Evrard, Anders Blomqvist, Jonathan O. Dostrovsky (2024) Interoception and AD (Bud) Craig's paradigm-shifting legacy Pain, Vol. 165, s. 1191-1193 (Artikel i tidskrift) Vidare till DOI
Silvia Castany Quintana, Priscila Batista Rosa, Kiseko Shionoya, Anders Blomqvist, David Engblom (2024) Social transmission of inflammation in mice Brain, behavior, and immunity, Vol. 120, s. 464-470 (Artikel i tidskrift) Vidare till DOI
Anders Blomqvist, Henry C. Evrard (2024) The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al Pain, Vol. 165, s. E15-E16 (Artikel i tidskrift) Vidare till DOI

2023

Anders Blomqvist (2023) Pain and temperature, and human awareness: The legacy of Bud Craig Temperature (Austin, Tex.), Vol. 10, s. 395-401 (Artikel i tidskrift) Vidare till DOI

Nyheter

Organisation