Fotografi av Anders Blomqvist

Anders Blomqvist

Professor emeritus

Mechanisms of immune-to-brain signaling

Peripheral inflammatory processes elicit a number of CNS mediated sickness responses, including fever, fatigue, depression, anorexia, social avoidance, and increased stress hormone release. We examine the mechanisms by which peripheral immune signals are monitored by the brain to elicit these symptoms, and in particular how these signals can circumvent the blood-brain barrier.

Using genetically modified mice with cell or tissue specific deletions of molecules involved in the inflammatory signaling cascade, or animals in which these molecules are selectively expressed in some cells/tissues, we study how peripherally released proinflammatory molecules activate blood-barrier cells, both in whole-body experiments and ex vivo in identified and isolated cells obtained by cell sorting techniques.

Using fever as a primary physiological read-out, being a readily monitored, quantifiable and standardized response to inflammation, we examine how peripherally released cytokines activate intracellular pathways that trigger prostaglandin synthesis, and we examine how the interaction between pyrogenic and cryogenic signals shape the temperature response to the immune challenge.

In a second associated line, we examine how peripheral inflammation as well as tumor generated messengers influence food intake and metabolism. Our work has implications for our understanding of the central processes involved in responding to acute and chronic peripheral inflammation and for finding novel treatments for the associated disease symptoms.

Postdoktorala tjänster tillgängliga

En 2-årig postdoktorandtjänst är ledig i mitt laboratorium

Den idealiska kandidaten bör ha en doktorsexamen i immunologi, neurovetenskap eller relaterade områden; djupgående laboratorieerfarenhet av att utföra oberoende forskning; goda kunskaper om molekylär och beteendemässig neurovetenskap, inklusive smådjursexperiment; och utmärkt engelsk tal- och skrivförmåga.

För att ansöka, skicka ett fullständigt CV, en kort sammanfattning av aktuell forskning, samt namn och kontaktinformation från två referenser till anders.blomqvist@liu.se

Publikationer

Utvalda publikationer

Omslag för publikation ''
Kiseko Shionoya, Anna Eskilsson, Anders Blomqvist (2022)

Proceedings of the National Academy of Sciences of the United States of America , Vol.119 Vidare till DOI

Omslag för publikation ''
Anna Eskilsson, Kiseko Shionoya, Sven Enerback, David Engblom, Anders Blomqvist (2020)

The FASEB Journal , Vol.34 , s.5863-5876 Vidare till DOI

Omslag för publikation ''
Anders Blomqvist, David Engblom (2018)

The Neuroscientist , Vol.24 , s.381-399 Vidare till DOI

Omslag för publikation ''
Anna Eskilsson, Takashi Matsuwaki, Kiseko Shionoya, Elahe Mirrasekhian, Joanna Zajdel, Markus Schwaninger, David Engblom, Anders Blomqvist (2017)

Journal of Neuroscience , Vol.37 , s.5035-5044 Vidare till DOI

Senaste publikationer i LiU DiVA

2023

Anna Eskilsson, Kiseko Shionoya, Anders Blomqvist (2023) Prostaglandin production in brain endothelial cells during the initiation of fever Communicative & Integrative Biology, Vol. 16, Artikel 2166237 Vidare till DOI
Anders Blomqvist (2023) Prostaglandin E-2 Production by Brain Endothelial Cells and the Generation of Fever DNA and Cell Biology, Vol. 42, s. 107-112 Vidare till DOI
Anders Blomqvist, Henry C. Evrard, Jonathan O. Dostrovsky, Irina A. Strigo, Wilfrid Jaenig (2023) OBITUARY: A. D. (Bud) Craig, Jr. (1951-2023) Nature Neuroscience Vidare till DOI
Kiseko Shionoya, Anna Nilsson, Linda Engström Ruud, David Engblom, Anders Blomqvist (2023) Melanocortin-4 receptors on neurons in the parabrachial nucleus mediate inflammation-induced suppression of food-seeking behavior Brain, behavior, and immunity, Vol. 110, s. 80-84 Vidare till DOI

2022

Kiseko Shionoya, Anna Eskilsson, Anders Blomqvist (2022) Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, Artikel e2122562119 Vidare till DOI

Nyheter

Organisation