För mer information om min forskning, se den engelska sidan (ovan till höger).
Francisca Lottersberger
Universitetslektor, Docent
Syftet med min forskning är att förstå hur integriteten i genomet upprätthålls, med särskild tonvikt på kromatinmobilitetens roll.
Genomintegritet: från kärnstruktur till telomerskydd
Forskningssida
Publikationer
Utvalda publikationer
- Faustini E, Dello Stritto A, Panza A, Doksani Y, Lottersberger F. (2025) Nuclear deformations increase PARPi sensitivity in BRCA1-deficient cells by altering DNA break mobility. Nat Commun. 2025 Jun 17;16(1):5326.
- Eickhoff P, Sonmez C, Fisher CEL, Inian O, Roumeliotis TI, Dello Stritto A, Mansfeld J, Choudhary JS, Guettler S, Lottersberger F*, Douglas ME*. (2025) Chromosome end protection by RAP1-mediated inhibition of DNA-PK. Nature. 2025 Apr 16. Epub ahead of print. *Co-corresponding authors.
- Doksani Y*, Lottersberger F*. (2024) News and views comment: The Risky business of ADP-ribosylating telomeric DNA. Nat Struct Mol Biol 2024 May;31(5):737-738. *Co-corresponding authors.
- Somnez C, Toia B, Eickhoff P, Matei AM, El Beyrouthy M, Wallner B, Douglas ME, de Lange T, Lottersberger F. (2024) DNA-PK controls Apollo’s access to leading-end telomeres. Nucleic Acids Res. 2024 Feb 26:gkae105.
- Faustini E, Longaretti M, Panza A, Lottersberger F. (2024) Quantification of nuclear deformations and DNA damage foci dynamics by live-cell imaging. Methods in Cell Biology. 2024;182:247-263.
- Myler LR*, Toia B*, Vaughan CK, Takai K, Matei AM, Wu P, Paull TT, de Lange T**, Lottersberger F **. (2023) DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres. Nat Struct Mol Biol 2023 Sep;30(9):1346-1356. *Equal contribution. **Co-corresponding authors. In News and views.
- Malinski B*, Vertemara J*, Faustini E*, E, Ladenvall C, Zhang Y, von Castelmur E, Baliakas P, Tisi R**, Cammenga J**, Lottersberger F**. (2023) Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, and telomerase activity. Hum Mol Genet. 2023 Sep 16;32(19):2901-2912. *Equal contribution. **Co-corresponding authors.
- Mirman Z*, Lottersberger F*, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature 2018 560: 112-116. *equal contribution.
- Lottersberger F, Karssemeijer RA, Dimitrova N, de Lange T. (2015) 53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair. Cell 2015 Nov 5;163(4):880-93. Featured Article.
Om mig
CV
- Master degree University of Milano-Bicocca, Italy - 2002
- Ph.D. University of Milano-Bicocca, Italy – 2006
- Post-doc University of Milano-Bicocca, Italy - 2006
- Post-doc The Rockefeller University, NY, USA - 2017
Undervisning
- Coordinator, examiner and lecturer for the courses “Molecular Genetics and Epigenetics (8BKG17)” for the Bachelor’s program in Experimental and Industrial Biomedicine and “Molecular Genetics and Gene technology (TVCB14)” for the Bachelor’s program in Biotechnology Engineering Biology.
- Mentor and examiner for the Master’s program in Experimental and Medical Biosciences (8MEA15, 8MEA20, 8MEA31).
- Guest lecturer in “Genome instability and Cancer” for the course “Tumor Biology” (8MEA21) of the Master’s program in Experimental and Medical Biosciences.
- Guest lecturer in “Cancer genetics” for the course “Molecular Genetics” (NBIC52) of the Bachelor’s programs in Biology, Chemistry, and Chemical Biology.
